Evidence map›Paper›PMID 36474260›Full record

ReviewBiology direct2022

Artificial genetic polymers against human pathologies.

Gleb S Ivanov, Vyacheslav G Tribulovich, Nikolay B Pestov, Temitope I David, Abdul-Saleem Amoah, Tatyana V Korneenko, Nikolai A Barlev

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology direct, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gleb S IvanovInstitute of Cytology, Tikhoretsky Ave 4, Saint Petersburg, Russia, 194064.
Vyacheslav G TribulovichSt. Petersburg State Technological Institute (Technical University), Saint Petersburg, Russia, 190013.
Nikolay B PestovChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Moscow, Russia, 108819.
Temitope I DavidPhystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia, 141701.
Abdul-Saleem AmoahPhystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia, 141701.
Tatyana V KorneenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia, 117997.
Nikolai A BarlevInstitute of Cytology, Tikhoretsky Ave 4, Saint Petersburg, Russia, 194064. nick.a.barlev@gmail.com.

Funding

This work was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers "Digital Biodesign and Personalized Healthcare" No 75-15-2020-913
6 · The paper itself

Abstract

Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.

Indexed as

Locked nucleic acidsPeptide nucleic acidsXenonucleic acids

Identifiers

PMID36474260
PMCPMC9727881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.