Evidence map›Paper›PMID 36474174›Full record

Observational studyBMC infectious diseases2022

COVID-19 vaccination side effects among the child age group: a large cross-sectional online based survey in Saudi Arabia.

Hassan Alwafi, Abdallah Y Naser, Abdulelah M Aldhahir, Ahmad Alhazmi, Areen Naif Alosaimi, Rasha Abdulaziz Mandili, Zaid Majeed, Emad Salawati, Rakan Ekram, Mohammed Samannodi and 5 more

Erratum issuedOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Hassan AlwafiDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Abdallah Y NaserDepartment of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan. abdallah.naser@iu.edu.jo.
Abdulelah M AldhahirRespiratory Therapy Department, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Ahmad AlhazmiDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Areen Naif AlosaimiDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Rasha Abdulaziz MandiliDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Zaid MajeedDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Emad SalawatiDepartment of Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Rakan EkramSchool of Public Health and Health Informatics, Umm Al-Qura University, Mecca, Saudi Arabia.
Mohammed SamannodiDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Hamza AssaggafDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca, Saudi Arabia.
Mohammed AlmatrafiDepartment of Pediatrics, Faculty of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Jaber S AlqahtaniDepartment of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammām, Saudi Arabia.
Safaa Mohammed AlsanosiDepartment of Pharmacology and Toxicology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Faisal MinshawiDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca, Saudi Arabia.
Umm al-Qura University · SAIsra University · JOJazan University · SAKing Abdulaziz University · SAPrince Sultan Military College of Health Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple vaccines have been tested in clinical trials for their efficacy and safety. In Saudi Arabia, Pfizer-BioNTech or Moderna were approved for children, however, previous studies to report their safety profile are limited. This research aims to understand the side effect of children's vaccination against SARS-CoV-2 infection in Saudi Arabia.

methodsThis was an observational retrospective cross-sectional study was conducted using an online survey in Saudi Arabia from March to May 2022. The inclusion criteria were parents aged 18 years and above who live in Saudi Arabia and have vaccinated their children. The self-reported questionnaire was adopted from published studies to investigate the study objectives Descriptive statistics were used to describe patients' demographic characteristics, continuous data were reported as mean ± S.D., categorical data were reported as percentages (frequencies), and logistic regression was used to identify predictors of persistent post-COVID-19 symptoms.

resultsThis study had a total of 4,069 participants. Only 41.9% of the participants reported that their child(ren) had been infected with the coronavirus. 2.00 was the median number of children (IQR: 1.00-4.00). More than half of the study participants (64.2%) reported that a family member had been infected with the coronavirus. Both parents received COVID-19 vaccination, according to most participants (88.7%). Most participants (70.5%) stated that all children who met the vaccination criteria had received the vaccine. Most participants (83.5%) said their child or children had two doses of their vaccine, and about half (50.4%) of those who received the vaccine reported experiencing side effects. In addition, the majority (78.9%) reported that the side effects appeared within one day of receiving the vaccine, and nearly two-thirds (65.7%) reported that the side effects lasted between one and three. A total of 11,831 side effects cases were documented. Pain at the injection site, hyperthermia, and fatigue were the most reported side effects, accounting for 15.3%, 14.1%, and 13.2%, respectively.

conclusionIt appears that the side effects of the COVID-19 vaccine for children are minor, tolerable, and like those described previously in clinical trials. Our data should encourage the public about the safety of receiving the COVID-19 vaccine for children.

Indexed as

COVID-19Drug-Related Side Effects and Adverse ReactionsChildCOVID-19 VaccinesCross-Sectional StudiesHumansRetrospective StudiesSARS-CoV-2COVID-19 VaccinesChildrenCOVID-19Saudi ArabiaSide effectsVaccination

Identifiers

PMID36474174
PMCPMC9724422
OpenAlexW4311572550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.