ReviewReviews in endocrine & metabolic disorders2023
Phase angle and cellular health: inflammation and oxidative damage.
Review in Reviews in endocrine & metabolic disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Preoperative bioelectrical impedance, measured phase angle, and hand-grip strength as predictors of postoperative outcomes in patients undergoing cardiac surgery: a systematic review.BMC cardiovascular disorders · 2024Pooled it
- Effect of lipid-based nutrient supplements on morbidity among children with stunting: secondary analysis of a randomized trial in Uganda.European journal of clinical nutrition · 2025Trial
- Does Resveratrol Impact Oxidative Stress Markers in Patients with Head and Neck Cancer Receiving Home Enteral Nutrition?Nutrients · 2025Trial
- Trial
- Comment on "Usefulness of the phase angle for inflammation criteria of the Global Leadership Initiative on Malnutrition in critically ill patients".Journal of anesthesia · 2026Article
- Article
- Lower bioelectrical phase angle is associated with audiometric hearing loss in middle-aged and older adults.GeroScience · 2026Article
- Comment on "Usefulness of the phase angle for inflammation criteria of the global leadership initiative on malnutrition in critically ill patients" by Kariya et al.Journal of anesthesia · 2026Article
- Effect of Remote Tai Chi Training vs. Strength Training on Muscle Mass and Grip Strength in Older Mexican Adults in the Context of the COVID-19 Pandemic.Sports (Basel, Switzerland) · 2026Article
- Initial Phase Angle Is Independently Associated With Functional Independence at 6 Months After Stroke.Geriatrics & gerontology international · 2026Observational
- Preoperative Bioelectrical Impedance Analysis Identifies Altered Body Composition, Which Is Associated with Severe Postoperative Complications in Major Hepatopancreaticobiliary Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Usefulness of the phase angle for inflammation criteria of the global leadership initiative on malnutrition in critically ill patients.Journal of anesthesia · 2026Article
- Phase Angle and Extracellular Water-to-Total Body Water Ratio Measured by Bioelectrical Impedance Analysis Are Associated with Anemia and Hemoglobin Levels in Women with Type 2 Diabetes: A Cross-Sectional Study.Health science reports · 2026Article
- Phase angle, extracellular to intracellular water ratio, and advanced glycation end products according to four sarcopenia categories and in relation to muscle strength/mass in elderly out-patients with diabetes.Diabetology international · 2026Article
- Reference values for bioelectrical impedance-derived phase angle: a cross-sectional study of 5,049 healthy individuals from Colombia.European journal of clinical nutrition · 2026Article
- Does a Muscle Fatigue-Inducing Protocol Alter the Magnitude of Jump Inter-Limb Asymmetry in Healthy Adolescents?Journal of human kinetics · 2026Article
- Baseline phase angle is associated with morphofunctional status, length of stay, and hospitalization costs in severe anorexia nervosa: the EDIGRA study.Journal of eating disorders · 2026Article
- Association Between Phase Angle and HbA1c in Non-elderly Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study Using Outpatient Clinical Data.Internal medicine (Tokyo, Japan) · 2026Article
- Applications of bioimpedance measurement in clinical and allied fields: a comprehensive review.Biomedical engineering online · 2026Review
- Association of the phase angle with type 2 diabetes and related traits: results from two prospective KORA studies.Nutrition & diabetes · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phase angle is a composite measure that combines two raw bioelectrical impedance analysis measures: resistance and reactance. Phase angle has been considered an indicator of cellular health, integrity, and hydration. As inflammation and oxidative stress can damage cellular structures, phase angle has potential utility in early detecting inflammatory and oxidative status. Herein, we aimed to critically review the current understanding on the determinants of phase angle and its relationship with markers of inflammation and oxidative stress. We also discussed the potential role of phase angle in detecting chronic inflammation and related adverse outcomes. Several factors have been identified as predictors of phase angle, including age, sex, extracellular to intracellular water ratio, and fat-free mass. In addition to these factors, body mass index (BMI) also seems to influence phase angle. Available data also show that lower phase angle values are correlated (negligible to high correlation coefficients) with higher c-reactive protein, tumour necrosis factor-α, interleukin-6, and interleukin-10 in studies involving the general and aging populations, as well as patients with chronic conditions. Although fewer studies have evaluated the relationship between phase angle and markers of oxidative stress, available data also suggest that phase angle has potential to be used as an indicator (for screening) of oxidative damage. Future studies including diverse populations and bioelectrical impedance devices are required to confirm the validity and accuracy of phase angle as a marker of inflammation and oxidative stress for clinical use.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.