ArticleMolecular psychiatry2023
Morphometric dis-similarity between cortical and subcortical areas underlies cognitive function and psychiatric symptomatology: a preadolescence study from ABCD.
Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Individual-Level Associations of Cognition and Personality With Adolescent Mental Health Vary Across Brain and Environmental Profiles.bioRxiv : the preprint server for biology · 2026Article
- Serum PFAS concentrations and neuromorphometry in adolescents: The HOME Study.Environmental research · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Gray Matter Morphological Networks are Associated with Neurobiological Features, Cognitive Status and Clinical Recovery in Traumatic Brain Injury.medRxiv : the preprint server for health sciences · 2026Article
- Dual-axis myelination covariance drives the functional connectivity emergence during infancy.Nature communications · 2026Article
- Comprehensive large-scale analyses reveal association between brain structure and cognitive ability during adolescence.Communications biology · 2026Article
- Cortical similarity networks in the rat brain: Postnatal development and sensitivity to early life stress.Network neuroscience (Cambridge, Mass.) · 2026Article
- Cortical morphometric inverse divergence alterations in first-episode, treatment-naïve COVID-19 secondary depression correlate with transcriptional signatures.BMC psychiatry · 2025Article
- Association between Brain Structure and Cognitive Ability during Adolescence: Insights from a Comprehensive Large-Scale Analysis of 9 to 15 Year-Olds.bioRxiv : the preprint server for biology · 2025Article
- The brain cortical similarity network: Development and sensitivity to early life stress in a rat model.bioRxiv : the preprint server for biology · 2025Article
- Estimating Brain Similarity Networks With Diffusion MRI.Human brain mapping · 2025Article
- Individual-level cortical morphological network analysis in idiopathic normal pressure hydrocephalus: diagnostic and prognostic insights.Fluids and barriers of the CNS · 2025Article
- Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Exploring the predictive value of structural covariance networks for the diagnosis of schizophrenia.Frontiers in psychiatry · 2025Article
- Structural MRI of brain similarity networks.Nature reviews. Neuroscience · 2025Review
- Human adolescent brain similarity development is different for paralimbic versus neocortical zones.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Predicting 'Brainage' in late childhood to adolescence (6-17yrs) using structural MRI, morphometric similarity, and machine learning.Scientific reports · 2023Article
- Predicting 'Brainage' in the Developmental Period using Structural MRI, Morphometric Similarity, and Machine Learning.Research square · 2023Article
- Cortical structural differences following repeated ayahuasca use hold molecular signatures.Frontiers in neuroscience · 2023Article
- The weight-adjusted-waist index and cognitive impairment among U.S. older adults: a population-based study.Frontiers in endocrinology · 2023Article
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Authors and funding
13 authors at 9 institutions in 6 countries.
Funding
Abstract
Preadolescence is a critical period characterized by dramatic morphological changes and accelerated cortico-subcortical development. Moreover, the coordinated development of cortical and subcortical regions underlies the emerging cognitive functions during this period. Deviations in this maturational coordination may underlie various psychiatric disorders that begin during preadolescence, but to date these deviations remain largely uncharted. We constructed a comprehensive whole-brain morphometric similarity network (MSN) from 17 neuroimaging modalities in a large preadolescence sample (N = 8908) from Adolescent Brain Cognitive Development (ABCD) study and investigated its association with 10 cognitive subscales and 27 psychiatric subscales or diagnoses. Based on the MSNs, each brain was clustered into five modules with distinct cytoarchitecture and evolutionary relevance. While morphometric correlation was positive within modules, it was negative between modules, especially between isocortical and paralimbic/subcortical modules; this developmental dissimilarity was genetically linked to synapse and neurogenesis. The cortico-subcortical dissimilarity becomes more pronounced longitudinally in healthy children, reflecting developmental differentiation of segregated cytoarchitectonic areas. Higher cortico-subcortical dissimilarity (between the isocortical and paralimbic/subcortical modules) were related to better cognitive performance. In comparison, children with poor modular differentiation between cortex and subcortex displayed higher burden of externalizing and internalizing symptoms. These results highlighted cortical-subcortical morphometric dissimilarity as a dynamic maturational marker of cognitive and psychiatric status during the preadolescent stage and provided insights into brain development.
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