Observational studyClinical autonomic research : official journal of the Clinical Autonomic Research Society2023
Orthostatic blood pressure adaptations, aortic stiffness, and central hemodynamics in the general population: insights from the Malmö Offspring Study (MOS).
Observational study in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis.BMJ (Clinical research ed.) · 2025Pooled it
- Orthostatic Hypertension: Clinical Spectrum and Gaps in Knowledge.Current hypertension reports · 2026Review
- Association of orthostatic hypertension identified according to different definitions with cardiovascular disease. The PARTAGE study.Journal of hypertension · 2026Article
- The relationship between physical activity, orthostatic blood pressure reactions and subclinical atherosclerosis: the Swedish CArdioPulmonary bioImage Study (SCAPIS).Journal of human hypertension · 2025Article
- Gender Difference in Orthostatic Vascular Stiffness Increase in Young Subjects.Diagnostics (Basel, Switzerland) · 2025Article
- Blood Pressure Regulation in Post-COVID POTS: Beyond Sinus Tachycardia.Hypertension (Dallas, Tex. : 1979) · 2024Article
- The Importance of Orthostatic Increase in Pulse Wave Velocity in the Diagnosis of Early Vascular Aging.Journal of clinical medicine · 2024Article
- Plasma Metabolome Predicts Aortic Stiffness and Future Risk of Coronary Artery Disease and Mortality After 23 Years of Follow-Up in the General Population.Journal of the American Heart Association · 2024Article
- Orthostatic hypotension is associated with higher levels of circulating endostatin.European heart journal open · 2024Article
- Preclinical Orthostatic Abnormalities May Predict Early Increase in Vascular Stiffness in Different Age Groups: A Pilot Study.Diagnostics (Basel, Switzerland) · 2023Article
- Orthostatic Hypertension: A Newcomer Among the Hypertension Phenotypes.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Utility of standing office blood pressure in detecting hypertension in healthy adults.Scientific reports · 2023Article
- Orthostatic hypertension-too much of a good thing.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Exaggerated blood pressure response to standing in young-to-middle-age subjects: prevalence and factors involved.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
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Authors and funding
6 authors.
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Abstract
purposeArterial stiffness is independently associated with orthostatic hypotension in older individuals. The relationship between orthostatic blood pressure adaptation and aortic stiffness has not been thoroughly examined in a younger population. We investigated the relationship between orthostatic blood pressure adaptations, central aortic hemodynamics, and aortic stiffness in a cohort of predominantly younger and middle-aged adults.
methodsWe analyzed an observational, population-based study of 5259 individuals living in Malmö, Sweden. We related aortic stiffness and central hemodynamics assessed by carotid-femoral pulse wave velocity and pulse wave analysis at the arteria radialis using Sphygmocor to orthostatic blood pressure adaptation after 3 min standing.
resultsThe mean age of the population was 41.9 ± 14.5 years, and 52.1% were women. We observed the highest aortic stiffness and central aortic blood pressure measurements in the lowest and highest quartiles of orthostatic systolic blood pressure differences (p < 0.001). Aortic stiffness and central aortic blood pressure gradually decreased across increasing quartiles of orthostatic diastolic blood pressure difference (p < 0.001). After full adjustment, orthostatic diastolic blood pressure remained significantly associated with aortic stiffness (p = 0.001) and central aortic blood pressure (p < 0.001), whereas orthostatic systolic blood pressure was significantly associated only with central aortic systolic blood pressure (p = 0.009). No significant associations were found between subclinical orthostatic hypotension, aortic stiffness, and central hemodynamics.
conclusionsOur findings demonstrate that altered blood pressure responses to orthostatic challenges, both blood pressure reductions and blood pressure increases, are independently and inversely associated with markers of aortic stiffness (vascular aging) in a predominantly young to middle-aged population.
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