ArticleInternational journal of impotence research2024
Sleep disorders are associated with testosterone deficiency and erectile dysfunction-a U.S. claims database analysis.
Article in International journal of impotence research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Association between restless legs syndrome and erectile dysfunction: a systematic review and meta-analysis.Sleep and biological rhythms · 2026Review
- Comparison of Insomnia Risk between Spironolactone and Esaxerenone in Individuals with Hypertension.JMA journal · 2026Article
- Review
- The role of sleep stages in the regulation of erectile function: impacts of REM sleep fragmentation.International journal of impotence research · 2026Review
- Exploring the link between comorbid insomnia and sleep apnea (COMISA) and erectile dysfunction: implications for male sexual health.Sexual medicine reviews · 2025Review
- Salivary steroids in acute central serous chorioretinopathy.International ophthalmology · 2025Observational
- Sleep-Related Eating Disorder and Sexsomnia; Two Rare Parasomnias? A Mini-Review with Illustrative Case-Reports.International journal of sexual health : official journal of the World Association for Sexual Health · 2025Article
- Causal relationship between sleep traits and erectile dysfunction: evidence from Mendelian randomization analysis.Archives of medical science : AMS · 2025Article
- Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian randomization study.Nature and science of sleep · 2025Article
- Does testosterone influence the association between sleep and frailty in men: results from the European Male Aging Study.BMC geriatrics · 2023Article
- Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers.International journal of environmental research and public health · 2023Article
- Impact of Symptoms of Late-Onset Hypogonadism as a Potential Driver of Presenteeism.American journal of men's healthArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between male genitourinary conditions and sleep disorders has previously only been reported in single-institution studies with small cohorts. Our objective was to assess the association of erectile dysfunction (ED) and testosterone deficiency with various sleep disorders using a large claims database. The TriNetX Diamond database was queried in June 2022. In men aged 40-70 years, insomnia, sleep apnea, and circadian rhythm sleep disorder were each independently assessed to determine the association with ED and testosterone deficiency and then followed by propensity score matching performed for age, hypertension, hyperlipidemia, diabetes mellitus, ischemic heart disease, tobacco usage, and obesity. Testosterone deficiency was more likely to be found in men diagnosed with sleep apnea (odds ratio (OR) 1.66 [95% confidence interval (CI) 1.65-1.67]), insomnia (OR 1.74 [95% CI 1.73-1.76]), and circadian rhythm dysfunction (OR 2.63 [95% CI 2.54-2.73]) compared to matched controls. ED was more likely to be found in men diagnosed with sleep apnea (OR 1.02 [95% CI 1.01-1.03]), insomnia (OR 1.30 [95% CI 1.30-1.31]), and circadian rhythm dysfunction (OR 1.54 [95% CI 1.49-1.59]) compared to matched controls. Our results emphasize the negative impact of poor sleep on diseases of the male genitourinary system by identifying these relationships in the largest cohort in the U.S. reported to date.
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