Evidence map›Paper›PMID 36473475›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2023

Open vs. robot-assisted radical cystectomy with extracorporeal or intracorporeal urinary diversion for bladder cancer A pairwise meta-analysis of outcomes and a network meta-analysis of complications.

Carlos Riveros, Sanjana Ranganathan, Cole Nipper, Kelvin Lim, Michael Brooks, Furkan Dursun, Brian J Miles, Alvin C Goh, Mihir Desai, Zachary Klaassen and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. [Etymology of the neobladder].Urologie (Heidelberg, Germany) · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Carlos RiverosDepartment of Urology, Houston Methodist Hospital, Houston, TX, United States.
Sanjana RanganathanDepartment of Urology, Houston Methodist Hospital, Houston, TX, United States.
Cole NipperDepartment of Urology, Houston Methodist Hospital, Houston, TX, United States.
Kelvin LimDepartment of Urology, Houston Methodist Hospital, Houston, TX, United States.
Michael BrooksDepartment of Urology, Houston Methodist Hospital, Houston, TX, United States.
Furkan DursunDepartment of Urology, University of Texas Health, San Antonio, TX, United States.
Brian J MilesDepartment of Urology, Houston Methodist Hospital, Houston, TX, United States.
Alvin C GohUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, NY, United States.
Mihir DesaiUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Zachary KlaassenDivision of Urology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Girish S KulkarniDivision of Urology and Surgical Oncology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada.
Christopher J D WallisDivision of Urology and Surgical Oncology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada.
Raj SatkunasivamDepartment of Urology, Houston Methodist Hospital, Houston, TX, United States.
Methodist Hospital · USAugusta University · USMemorial Sloan Kettering Cancer Center · USMount Sinai Hospital · CAThe University of Texas Health Science Center at San Antonio · USUniversity Health Network · CAUniversity of Southern California · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

introductionThere are no meta-analyses of randomized controlled trials (RCTs) comparing open radical cystectomy (OR C) with robot-assisted radical cystectomy (RARC), inclusive of both intracorporeal (iRARC) and extracorporeal (hybrid RARC, hRARC) urinary reconstruction.

methodsMEDL INE, Embase, Scopus, the International Clinical Trials Registry Platform and ClinicalTrials.gov registries were searched in May 2022. Outcomes of interest included recurrence- or progression-free survival (RFS/PFS), margin status and lymph node yield, mean estimated blood loss (EBL) and operating room time (ORT ), hospital length of stay (LOS ), 90-day complications and readmissions, and quality of life (QoL). Pairwise meta-analyses and network meta-analyses were performed using random-effects models and Bayesian hierarchical random-effects models, respectively.

resultsWe found no significant differences between RARC and OR C for oncological and most perioperative outcomes: RFS/PFS (hazard ratio [HR ] 0.91, 95% confidence interval [CI] 0.67-1.23); positive surgical margins (odds ratio [OR ] 1.05, 95% CI 0.60-1.85); lymph node yield (mean difference [MD ] -0.63, 95% CI -2.63-1.37); LOS (MD -0.22, 95% CI -1.10-0.65); overall complications (OR 0.81, 95% CI 0.61-1.07); major complications (OR 0.94, 95% CI 0.69-1.30); readmissions (OR 0.90, 95% CI 0.60-1.35); and QoL (standardized MD -0.02, 95% CI -0.17-0.14). We found significantly lower EBL for RARC compared to OR C (MD -312.61, 95% CI -447 to -178.22) at the expense of significantly prolonged ORT (MD 82.34 minutes, 95% CI 44.82-119.86). Network meta-analysis did not find significant differences in complications between hRARC and iRARC.

conclusionsThis meta-analysis confirms the equivalence of RARC and OR C with respect to oncological outcomes.

Identifiers

PMID36473475
PMCPMC10027355
OpenAlexW4307256987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.