Evidence map›Paper›PMID 36473468›Full record

ArticleImmunity2022

Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development.

Ji-Eun Kim, Bo Li, Lijiang Fei, Rachael Horne, Dorothy Lee, Adrian Kwan Loe, Hiromu Miyake, Eda Ayar, Dae-Kyum Kim, Michael G Surette and 5 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
7.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
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  4. Article
  5. Intestinal muscularis in health and disease.Communications biology · 2026
    Review
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  12. Article
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  14. Frontiers in nutrition · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Ji-Eun KimProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Bo LiGeneral and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
Lijiang FeiCenter for Stem Cell and Regenerative Medicine, Zhejiang University of School of Medicine, Hangzhou 310058, China.
Rachael HorneProgram in Cell Biology, Division of Gastroenterology, Hepatology & Nutrition, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Dorothy LeeGeneral and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
Adrian Kwan LoeProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Hiromu MiyakeGeneral and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
Eda AyarProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Dae-Kyum KimCenter for Personalized Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Michael G SuretteDepartment of Biochemistry and Biomedical Sciences, Department of Medicine, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L8, Canada.
Dana J PhilpottDepartment of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Philip ShermanProgram in Cell Biology, Division of Gastroenterology, Hepatology & Nutrition, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Guoji GuoCenter for Stem Cell and Regenerative Medicine, Zhejiang University of School of Medicine, Hangzhou 310058, China.
Agostino PierroGeneral and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
Tae-Hee KimProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: tae-hee.kim@sickkids.ca.
University of Toronto · CAZhejiang University · CNMcMaster University · CARoswell Park Comprehensive Cancer Center · US

Funding

CIHR IOP-92890CIHR MOP-89894CIHR PJT 155923
6 · The paper itself

Abstract

Intestinal stem cell maturation and development coincide with gut microbiota exposure after birth. Here, we investigated how early life microbial exposure, and disruption of this process, impacts the intestinal stem cell niche and development. Single-cell transcriptional analysis revealed impaired stem cell differentiation into Paneth cells and macrophage specification upon antibiotic treatment in early life. Mouse genetic and organoid co-culture experiments demonstrated that a CD206

Indexed as

Enterocolitis, NecrotizingGastrointestinal MicrobiomeAnimalsCell DifferentiationMacrophagesMicePaneth Cellsantibioticsintestinemacrophagesmicrobiotanecrotizing enterocolitisPaneth cellsstem cell nicheWnt signaling

Identifiers

PMID36473468
OpenAlexW4311668214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.