ArticleCell reports. Medicine2022
Selective and replicable neuroimaging-based indicators of pain discriminability.
Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The efficacy and mechanisms of low-intensity transcranial ultrasound stimulation on pain: a systematic review of human and animal studies.The journal of headache and pain · 2025Pooled it
- Intensity-dependent topographical expansion of sensory representations.bioRxiv : the preprint server for biology · 2026Article
- AQMFB-DWT: A Preprocessing Technique for Removing Blink Artifacts Before Extracting Pain-evoked Potential EEG.Neuroscience bulletin · 2025Article
- Electroencephalographic correlates of pain catastrophizing in chronic musculoskeletal pain: a scoping review.Pain management · 2025Article
- Perceived sensorimotor synchrony enhances pain modulation and attenuates laser-evoked potentials.Communications biology · 2025Article
- A Replicable and Generalizable Neuroimaging-Based Indicator of Pain Sensitivity Across Individuals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Neural variability reliably encodes interindividual differences in the perception of pain intensity.PLoS biology · 2025Article
- A comprehensive EEG dataset of laser-evoked potentials for pain research.Scientific data · 2025Article
- The analgesic effect and neural mechanism of spicy food intake.Social cognitive and affective neuroscience · 2025Article
- Decoding Pain: A Comprehensive Review of Computational Intelligence Methods in Electroencephalography-Based Brain-Computer Interfaces.Diagnostics (Basel, Switzerland) · 2025Review
- The Different Effects of Firsthand Pain and Nonpain Electrical Stimulation on Pain Empathy: An EEG Study.Pain research & management · 2025Article
- Pain-Discriminating Information Decoded From Spatiotemporal Patterns of Hemodynamic Responses Measured by fMRI in the Human Brain.Human brain mapping · 2024Article
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- The mutual influences between working memory and empathy for pain: the role of social distance.Social cognitive and affective neuroscience · 2024Article
- Age-associated changes in multimodal pain perception.Age and ageing · 2024Article
- Deciphering Authentic Nociceptive Thalamic Responses in Rats.Research (Washington, D.C.) · 2024Article
- Intact painful sensation but enhanced non-painful sensation in individuals with autistic traits.Frontiers in psychiatry · 2024Article
- The influence of aggressive exercise on responses to self-perceived and others' pain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural indicators of pain discriminability have far-reaching theoretical and clinical implications but have been largely overlooked previously. Here, to directly identify the neural basis of pain discriminability, we apply signal detection theory to three EEG (Datasets 1-3, total N = 366) and two fMRI (Datasets 4-5, total N = 399) datasets where participants receive transient stimuli of four sensory modalities (pain, touch, audition, and vision) and two intensities (high and low) and report perceptual ratings. Datasets 1 and 4 are used for exploration and others for validation. We find that most pain-evoked EEG and fMRI brain responses robustly encode pain discriminability, which is well replicated in validation datasets. The neural indicators are also pain selective since they cannot track tactile, auditory, or visual discriminability, even though perceptual ratings and sensory discriminability are well matched between modalities. Overall, we provide compelling evidence that pain-evoked brain responses can serve as replicable and selective neural indicators of pain discriminability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.