Evidence map›Paper›PMID 36473461›Full record

ArticleDevelopmental cell2022

Mouse placenta fetal macrophages arise from endothelial cells outside the placenta.

Xiaowen Chen, Alan T Tang, Joanna Tober, Jisheng Yang, N Adrian Leu, Stephanie Sterling, Mei Chen, Yiqing Yang, Patricia Mericko-Ishizuka, Nancy A Speck and 1 more

Open access · greenAbstract read
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Macrophages in embryonic development.Nature reviews. Immunology · 2026
    Review
  3. Article
  4. Article
  5. Feto-placental blood vessel development.Development (Cambridge, England) · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. AssessingFrontiers in immunology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiaowen ChenCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alan T TangCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joanna ToberDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jisheng YangCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
N Adrian LeuTransgenic Mouse Core, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Stephanie SterlingTransgenic Mouse Core, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mei ChenCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yiqing YangCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Patricia Mericko-IshizukaCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nancy A SpeckDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mark L KahnCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: markkahn@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Biochemistry of Leukemia Virus Core-Binding FactorR01HL091724 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SPECK, NANCY · 2008 to 2024
$8.3M
MEKK3 signaling in hemogenic endotheliumR01HL142976 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAHN, MARK L · 2018 to 2021
$3.2M
BIOCHEMISTRY OF LEUKEMIA VIRUS CORE-BINDING FACTORR01CA058343 · NCI · DARTMOUTH COLLEGE · PI SPECK, NANCY ASMUSSEN · 1993 to 2007
$3.0M
Lymphothrombosis in gut health and diseaseR01DK123528 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E, KAHN, MARK L · 2019 to 2023
$2.0M
NCI NIH HHS R01 CA058343NHLBI NIH HHS R01 HL091724NHLBI NIH HHS R01 HL142976NIDDK NIH HHS R01 DK123528
6 · The paper itself

Abstract

Placental fetal macrophages (fMacs) are the only immune cells on the fetal side of the placental barrier. Mouse models have not been used to test their function because they have previously been found to have distinct cellular origins and functions in mice and humans. Here, we test the ontogeny of mouse placental fMacs. Using a new Hoxa13

Indexed as

Endothelial CellsPlacentaAnimalsFemaleHumansMicePregnancyendotheliumHofbauer cellmacrophageplacenta

Identifiers

PMID36473461
PMCPMC9752200
OpenAlexW4311666179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.