Evidence map›Paper›PMID 36473166›Full record

ArticleACS chemical neuroscience2022

FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT

Tanishka S Saraf, Ryan P McGlynn, Omkar M Bhatavdekar, Raymond G Booth, Clinton E Canal

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Altered brain serotonin 5-HTNeuropharmacology · 2024
    Article
  6. Article
  7. Article
  8. The PsychedelicACS pharmacology & translational science · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tanishka S SarafDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.ORCID 0000-0002-4425-2109
Ryan P McGlynnCenter for Drug Discovery, Department of Pharmaceutical Sciences, and Department of Chemistry and Chemical Biology, Northeastern University, 300 Huntington Street, Boston, Massachusetts 02115, United States.
Omkar M BhatavdekarDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Croft Hall B27, Baltimore, Maryland 21218, United States.
Raymond G BoothCenter for Drug Discovery, Department of Pharmaceutical Sciences, and Department of Chemistry and Chemical Biology, Northeastern University, 300 Huntington Street, Boston, Massachusetts 02115, United States.
Clinton E CanalDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.ORCID 0000-0002-7940-933X
Mercer University Health Sciences Center · USNortheastern University · USJohns Hopkins University · US

Funding

Targeting Serotonin 5-HT1A and 5-HT7 Receptors to Prevent Audiogenic Seizures and Correct Translationally Valid EEG Phenotypes in a Juvenile Fmr1 Knock-Out Mouse Model of Fragile X SyndromeR15NS118352 · NINDS · MERCER UNIVERSITY MACON · PI CANAL, CLINTON E · 2020 to 2020
$424k
NINDS NIH HHS R15 NS118352
6 · The paper itself

Abstract

There are no approved medicines for fragile X syndrome (FXS), a monogenic, neurodevelopmental disorder. Electroencephalogram (EEG) studies show alterations in resting-state cortical EEG spectra, such as increased gamma-band power, in patients with FXS that are also observed in

Indexed as

Auditory CortexFragile X SyndromeSerotonin 5-HT1 Receptor AgonistsAdultAnimalsDisease Models, AnimalElectroencephalographyFemaleFragile X Messenger Ribonucleoprotein 1HumansMaleMiceMice, KnockoutReceptor, Serotonin, 5-HT1DSerotoninTetrahydronaphthalenes2-aminotetralinFMR1 protein, humanFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Receptor, Serotonin, 5-HT1DSerotoninSerotonin 5-HT1 Receptor AgonistsTetrahydronaphthalenes5-HT1alpha powerdelta powerEEGFmr1gamma powerserotonin

Identifiers

PMID36473166
PMCPMC10364582
OpenAlexW4313214661

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.