ArticleInternational urology and nephrology2023
Association between the triglyceride-glucose index and chronic kidney disease in adults.
Article in International urology and nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 39 citations in OpenAlex.
- Triglyceride-glucose index associated with the risk of future renal function decline: a 13-year prospective cohort study.Scientific reports · 2026Article
- Re-evaluation of the prognosis of patients with IgA nephropathy and mild proteinuria: a longitudinal study with unexpected results.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- TyG index is associated with microalbuminuria in a large population-based study: independent and exploratory interaction analyses.PloS one · 2026Article
- Triglyceride-glucose-based indices in relation to vitamin D concentrations among adults with metabolic syndrome.PloS one · 2026Article
- Article
- The Identification of Biomarkers and Therapeutic Targets for Diabetic Kidney Disease by Integrating the Proteome with the Genome.Biomedicines · 2025Article
- Association between triglyceride-glucose index and its composite obesity indexes and cardio-renal disease: analysis of the NHANES 2013-2018 cycle.Frontiers in endocrinology · 2025Article
- Predictive value of the triglyceride-glucose index for adverse clinical outcomes in chronic kidney disease.Frontiers in endocrinology · 2025Article
- Observational
- The cross-sectional association between cardiometabolic index and abdominal aortic calcification in U.S. adults: evidence from NHANES 2013-2014.Frontiers in nutrition · 2025Article
- Association between triglyceride-glucose index and cardiovascular disease in US adults with chronic kidney disease: a population-based study.BMC cardiovascular disorders · 2024Article
- Identification and optimization of relevant factors for chronic kidney disease in abdominal obesity patients by machine learning methods: insights from NHANES 2005-2018.Lipids in health and disease · 2024Article
- Association between triglyceride-glucose index and chronic kidney disease: results from NHANES 1999-2020.International urology and nephrology · 2024Article
- The U-shape relationship between insulin resistance-related indexes and chronic kidney disease: a retrospective cohort study from National Health and Nutrition Examination Survey 2007-2016.Diabetology & metabolic syndrome · 2024Article
- Baseline and usual triglyceride-glucose index and the risk of chronic kidney disease: a prospective cohort study.GeroScience · 2024Article
- Association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute coronary syndrome: results from the Improving Care for Cardiovascular Disease in China (CCC)-Acute Coronary Syndrome project.Cardiovascular diabetology · 2024Observational
- Association between the triglyceride-glucose index and subclinical left ventricular systolic dysfunction in obese patients.Cardiovascular diabetology · 2024Article
- Identification of risk factors and development of a predictive model for chronic kidney disease in patients with obesity: a four-year cohort study.Lipids in health and disease · 2024Article
- Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study.Journal of medical biochemistry · 2024Article
- Association of long-term triglyceride-glucose index patterns with the incidence of chronic kidney disease among non-diabetic population: evidence from a functional community cohort.Cardiovascular diabetology · 2024Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundChronic kidney disease (CKD) is characterized as a progressive dysfunction of the kidney, and it might have a close relationship with insulin resistance. We utilized the triglyceride-glucose (TyG) index, a reliable marker of insulin resistance, to evaluate the association between the TyG index and CKD in adults from the general population.
methodsThis was a cross-sectional study obtaining data from the 2015-2018 National Health and Nutrition Examination Survey. The estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) served as kidney function indicators. We defined CKD as the existence of either low eGFR (eGFR < 60 mL/min/1.73 m
resultsFor 4361 recruited participants, the mean TyG index was 8.60 ± 0.68, and the prevalence of CKD was 13.35%. Participants with a higher TyG index showed a higher UACR level (β = 25.10, 95% CI: 6.76, 43.44, P = 0.0074) and higher levels of CKD (OR = 1.34, 95% CI: 1.13, 1.59, P = 0.0006). The positive relationship between the TyG index and CKD became stronger and remained significant in the overweight (OR = 1.61, 95% CI: 1.18, 2.20, P = 0.0027) and obese (OR = 2.48, 95% CI: 1.95, 3.15, P < 0.0001) groups and in people with diabetes (OR = 1.94, 95% CI: 1.46, 2.56, P < 0.0001).
conclusionsHigher TyG index was strongly associated with a higher UACR level and higher values of albuminuria and CKD, which might be useful in kidney function screening especially among people in disadvantageous socioeconomic conditions with no availability for direct measurement of kidney function. However, more well-designed studies are still needed to validate this relationship.
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