Evidence map›Paper›PMID 36472794›Full record

ArticleHead and neck pathology2023

Immunohistochemical Characterization of Gingival Fibromas.

Mark Darling, Kunning Li, Keeley Burnside, Nicole Smith, Linda Jackson-Boeters, Douglas Hamilton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mark DarlingUniversity of Western Ontario, London, ON, Canada. mdarlin@uwo.ca.
Kunning LiUniversity of Western Ontario, London, ON, Canada.
Keeley BurnsideUniversity of Western Ontario, London, ON, Canada.
Nicole SmithUniversity of Western Ontario, London, ON, Canada.
Linda Jackson-BoetersUniversity of Western Ontario, London, ON, Canada.
Douglas HamiltonUniversity of Western Ontario, London, ON, Canada.
Western University · CA

Funding

Schulich School of Medicine and Dentistry Grant number R3586A06 UWO Internal Pathology code THHT.
6 · The paper itself

Abstract

purposeGingival fibromas (GFs) are fibrous lesions of the gingiva that are not well defined in the literature. They are histologically similar to peripheral ossifying fibromas (POFs), both being characterized as cellular proliferations of dense fibrous tissue, with POFs differing in that they demonstrate foci of calcification. This study aims to expand upon the immunohistochemical characterization of GFs, and to confirm their osteoblastic phenotype.

methodsFormalin fixed, paraffin embedded GFs, POFs and fibroepithelial polyps (FEPs) of the gingiva were examined. Immunohistochemical staining was performed for special AT-rich sequence binding protein 2 (SATB2), runt-related transcription factor 2 (RUNX2), osteocalcin and alpha-smooth muscle actin (αSMA). Sections were evaluated by light microscopy and the immunohistochemical staining patterns were assigned immunoreactive scores (IRS) based on percentage of stained cells and intensity of staining.

resultsGFs, POFs, and FEPs of the gingiva expressed osteoblastic markers SATB2, RUNX2 and osteocalcin. GFs and POFs expressed αSMA while FEPs of the gingiva did not. GFs and POFs had similar staining patterns of SATB2, RUNX2 and αSMA. DISCUSSION: These findings demonstrate that GFs and POFs exhibit a similar immunohistochemical profile, and supports a theory that GFs are osteoblastic lesions possibly related to POFs.

Indexed as

CalcinosisFibroma, OssifyingGingival NeoplasmsCore Binding Factor Alpha 1 SubunitHumansImmunohistochemistryOsteocalcinCore Binding Factor Alpha 1 SubunitOsteocalcinFibroepithelial polyps of the gingivaGingival fibromaGingival lesionsPeripheral ossifying fibroma

Identifiers

PMID36472794
PMCPMC10293518
OpenAlexW4310772627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.