Evidence map›Paper›PMID 36472656›Full record

ReviewPediatric nephrology (Berlin, Germany)2023

Glomerular hyperfiltration: part 2-clinical significance in children.

Oyindamola C Adebayo, Agathe B Nkoy, Lambertus P van den Heuvel, Veerle Labarque, Elena Levtchenko, Pierre Delanaye, Hans Pottel

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Proteinuria in adolescence.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  3. Observational
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Chronic kidney disease in children: an update.Clinical kidney journal · 2023
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Oyindamola C Adebayo *Center of Vascular and Molecular Biology, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium.ORCID http://orcid.org/0000-0001-5076-9983
Agathe B Nkoy *Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium.ORCID http://orcid.org/0000-0002-1563-380X
Lambertus P van den HeuvelLaboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium.ORCID http://orcid.org/0000-0003-3917-6727
Veerle LabarqueCenter of Vascular and Molecular Biology, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium.ORCID http://orcid.org/0000-0002-5052-9274
Elena LevtchenkoLaboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium.ORCID http://orcid.org/0000-0002-8352-7312
Pierre DelanayeDepartment of Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium.
Hans PottelDepartment of Public Health and Primary Care, Katholieke Universiteit Leuven, Campus Kulak, 8500 Kortrijk, Belgium. hans.pottel@kuleuven.be.ORCID http://orcid.org/0000-0003-0074-8919
KU Leuven · BEDepartment of Public Health · MMRadboud University Nijmegen · NLUniversity of Kinshasa · CDUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal dominant polycystic kidney disease, and solitary functioning kidney. Yet, the pathophysiological mechanisms vary from one disease to another and are not well understood. More so, it has been demonstrated that GHF may occur at the single-nephron in some clinical conditions while in others at the whole-kidney level. In this review, we explore the pathophysiological mechanisms of GHF in relation to various clinical conditions in the pediatric population. In addition, we discuss the role and mechanism of action of important factors such as gender, low birth weight, and race in the pathogenesis of GHF. Finally, in this current review, we further highlight the consequences of GHF in the progression of kidney disease.

Indexed as

Clinical RelevancePolycystic Kidney, Autosomal DominantChildGlomerular Filtration RateHumansKidneyKidney GlomerulusAutosomal dominant polycystic kidney disease (ADPKD)Diabetic kidney diseaseDuchenne muscular dystrophyGlomerular hyperfiltrationObesity-related glomerulopathyPediatric populationSickle cell diseaseSolitary functioning kidney

Identifiers

PMID36472656
OpenAlexW4310775271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.