Evidence map›Paper›PMID 36472537›Full record

ArticleRadiology2023

Risk of Acute Kidney Injury Following Contrast-enhanced CT in a Cohort of 10 407 Children and Adolescents.

Juan Calle-Toro, Bernarda Viteri, Lance Ballester, Herney Andrés García-Perdomo, Ammie White, Madhura Pradhan, Hansel J Otero

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. The Safety of Ultrasound Contrast Agents in Children.Diagnostics (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. New approaches to acute kidney injury.Clinical kidney journal · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 4 countries.

Juan Calle-Toro *From the Division of Body Imaging, Department of Radiology (J.C.T., B.V., A.W., H.J.O.), Division of Nephrology, Department of Pediatrics (B.V., M.P.), and Biostatistics and Data Management Core (L.B.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Epidemiology, Universidad de la Frontera, Temuco, Chile (J.C.T., H.A.G.P.); Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.V., A.W., M.P., H.J.O.); and Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia (H.A.G.P.).ORCID 0000-0002-6944-7471
Bernarda Viteri *From the Division of Body Imaging, Department of Radiology (J.C.T., B.V., A.W., H.J.O.), Division of Nephrology, Department of Pediatrics (B.V., M.P.), and Biostatistics and Data Management Core (L.B.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Epidemiology, Universidad de la Frontera, Temuco, Chile (J.C.T., H.A.G.P.); Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.V., A.W., M.P., H.J.O.); and Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia (H.A.G.P.).
Lance BallesterFrom the Division of Body Imaging, Department of Radiology (J.C.T., B.V., A.W., H.J.O.), Division of Nephrology, Department of Pediatrics (B.V., M.P.), and Biostatistics and Data Management Core (L.B.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Epidemiology, Universidad de la Frontera, Temuco, Chile (J.C.T., H.A.G.P.); Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.V., A.W., M.P., H.J.O.); and Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia (H.A.G.P.).ORCID 0000-0002-1486-7137
Herney Andrés García-PerdomoFrom the Division of Body Imaging, Department of Radiology (J.C.T., B.V., A.W., H.J.O.), Division of Nephrology, Department of Pediatrics (B.V., M.P.), and Biostatistics and Data Management Core (L.B.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Epidemiology, Universidad de la Frontera, Temuco, Chile (J.C.T., H.A.G.P.); Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.V., A.W., M.P., H.J.O.); and Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia (H.A.G.P.).ORCID 0000-0001-6945-8261
Ammie WhiteFrom the Division of Body Imaging, Department of Radiology (J.C.T., B.V., A.W., H.J.O.), Division of Nephrology, Department of Pediatrics (B.V., M.P.), and Biostatistics and Data Management Core (L.B.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Epidemiology, Universidad de la Frontera, Temuco, Chile (J.C.T., H.A.G.P.); Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.V., A.W., M.P., H.J.O.); and Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia (H.A.G.P.).ORCID 0000-0001-8949-2539
Madhura PradhanFrom the Division of Body Imaging, Department of Radiology (J.C.T., B.V., A.W., H.J.O.), Division of Nephrology, Department of Pediatrics (B.V., M.P.), and Biostatistics and Data Management Core (L.B.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Epidemiology, Universidad de la Frontera, Temuco, Chile (J.C.T., H.A.G.P.); Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.V., A.W., M.P., H.J.O.); and Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia (H.A.G.P.).
Hansel J OteroFrom the Division of Body Imaging, Department of Radiology (J.C.T., B.V., A.W., H.J.O.), Division of Nephrology, Department of Pediatrics (B.V., M.P.), and Biostatistics and Data Management Core (L.B.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Epidemiology, Universidad de la Frontera, Temuco, Chile (J.C.T., H.A.G.P.); Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.V., A.W., M.P., H.J.O.); and Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia (H.A.G.P.).ORCID 0000-0003-4626-0732
Children's Hospital of Philadelphia · USUniversidad de La Frontera · CL

Funding

Training in Renal ResearchT32DK007006 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HOLZMAN, LAWRENCE B. · 1986 to 2023
$8.5M
IMPAKT Study: Imaging Modalities in Pediatric Assessments of Kidney TransplantsK23DK131331 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Bernarda Viteri Baquerizo · 2022 to 2026
$899k
NIDDK NIH HHS K23 DK131331NIDDK NIH HHS T32 DK007006
6 · The paper itself

Abstract

Background Previous studies have challenged the concept of contrast material-induced acute kidney injury (AKI) in adults; however, limited data exist for children and adolescents. Purpose To calculate the incidence and determine the risks of AKI in patients who received intravenous iodinated contrast media for CT. Materials and Methods This retrospective study was performed at a children's hospital from January 2008 to January 2018 and included patients aged 0-17 years in whom serum creatinine levels were measured within 48 hours before and after CT with or without contrast media. The incidence of AKI was measured according to the AKI Network guidelines. A subgroup analysis with propensity score matching of cases with control patients was performed. Differences before and after stratification based on estimated glomerular filtration rate (eGFR) were explored. Adjusted risk models were developed using log-binomial generalized estimating equations to estimate relative risk (RR). Results From a total of 54 000 CT scans, 19 377 scans from 10 407 patients (median age, 8.5 years; IQR, 3-14; 5869 boys, 4538 girls) were included in the analysis. Incidence rate of AKI for the entire sample was 1.5%; it was 1.4% (123 of 8844) in the group that underwent contrast-enhanced CT and 1.6% (171 of 10 533) in the group that did not (

Indexed as

Acute Kidney InjuryDrug-Related Side Effects and Adverse ReactionsAdolescentAdultChildContrast MediaFemaleGlomerular Filtration RateHumansMaleRetrospective StudiesRisk FactorsTomography, X-Ray ComputedContrast Media

Identifiers

PMID36472537
PMCPMC10050109
OpenAlexW4310778647

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.