Evidence map›Paper›PMID 36472421›Full record

ArticleMicrobiology spectrum2023

Pseudomonas aeruginosa Promotes Persistence of Stenotrophomonas maltophilia via Increased Adherence to Depolarized Respiratory Epithelium.

Melissa S McDaniel, Natalie R Lindgren, Caitlin E Billiot, Kristina N Valladares, Nicholas A Sumpter, W Edward Swords

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. A quorum-sensing molecule fromProceedings of the National Academy of Sciences of the United States of America · 2026
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  4. Microbiology spectrum · 2025
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  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Comparative genomics of clinicalMicrobiology (Reading, England) · 2023
    Article
  13. Improved mini-TnApplied and environmental microbiology · 2023
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Melissa S McDanielDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-5178-842X
Natalie R LindgrenDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-3851-6964
Caitlin E BilliotDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-9947-5695
Kristina N ValladaresDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-1908-0122
Nicholas A SumpterDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-0451-9024
W Edward SwordsDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-4063-940X
University of Alabama at Birmingham · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0M
UAB Predoctoral Training Program in Lung DiseasesT32HL134640 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SWORDS, WILLIAM E · 2017 to 2021
$1.0M
NHLBI NIH HHS T32 HL134640NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

Stenotrophomonas maltophilia is an emerging opportunistic respiratory pathogen in people with cystic fibrosis (CF). S. maltophilia is frequently observed in polymicrobial infections, and we have previously shown that Pseudomonas aeruginosa promotes colonization and persistence of S. maltophilia in mouse respiratory infections. In this study, we used host and bacterial RNA sequencing to further understand the molecular underpinnings of this interaction. To evaluate S. maltophilia transcript profiles, we used a recently described method for selective capture of bacterial mRNA transcripts with strain-specific RNA probes. We found that factors associated with the type IV pilus, including the histidine kinase subunit of a chemotactic two-component signaling system (

Indexed as

Cystic FibrosisGram-Negative Bacterial InfectionsStenotrophomonas maltophiliaAnimalsEpithelial CellsHumansMicePseudomonas aeruginosaRespiratory Mucosaadherencecystic fibrosispiluspolymicrobial infectionPseudomonas aeruginosarespiratory epitheliumStenotrophomonas maltophiliatype IV pilus

Identifiers

PMID36472421
PMCPMC9927254
OpenAlexW4310785196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.