ArticleEcho research and practice2020
Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review.
Article in Echo research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Global Longitudinal Strain and Brain Natriuretic Peptide as Prognostic Biomarkers for Asymptomatic Severe Aortic Regurgitation With Preserved Ejection Fraction: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2026Article
- Cardiac Imaging Predictors of Ventricular Recovery in Pediatric Patients Undergoing Aortic Valve Intervention for Regurgitation.Pediatric cardiology · 2026Article
- Three-dimensional transesophageal echocardiography and speckle tracking echocardiography in left-sided native valve infective endocarditis: analysis of valvular and ventricular parameters predictors of outcome.The international journal of cardiovascular imaging · 2025Article
- Global Longitudinal Strain as a Prognostic Biomarker for Asymptomatic Moderate to Severe Aortic Regurgitation with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Echocardiographic assessment of aortic regurgitation: a practical guideline from the British Society of Echocardiography.Echo research and practice · 2025Review
- Strain assessment in patients with aortic regurgitation undergoing transcatheter aortic valve implantation: case series.European heart journal. Case reports · 2024Article
- Aortic Regurgitation: From Valvular to Myocardial Dysfunction.Journal of clinical medicine · 2024Review
- Echocardiographic assessment of aortic regurgitation: a narrative review.Echo research and practice · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic aortic regurgitation (AR) patients typically remain asymptomatic for a long time. Left ventricular mechanics, namely global longitudinal strain (GLS), has been associated with outcomes in AR patients. The authors conducted a systematic review to summarize and appraise GLS impact on mortality, the need for aortic valve replacement (AVR) and disease progression in AR patients. A literature search was performed using these key terms 'aortic regurgitation' and 'longitudinal strain' looking at all randomized and nonrandomized studies conducted on chronic aortic regurgitation. The search yielded six observational studies published from 2011 and 2018 with a total of 1571 patients with moderate to severe chronic AR. Only two studies included all-cause mortality as their endpoint. The other studies looked at the association between GLS with AVR and disease progression. The mean follow-up period was 4.2 years. We noted a great variability of clinical, methodological and/or statistical origin. Thus, meta-analytic portion of our study was limited. Despite a relevant heterogeneity, an impaired GLS was associated with adverse cardiac outcomes. Left ventricular GLS may offer incremental value in risk stratification and decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.