Evidence map›Paper›PMID 36471692›Full record

Trial reportDrug design, development and therapy2022

Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.

Fan Zhang, Huan Chang, Wenxiang Qing, Rili Yu, Qin Liao, Jianbin Tong

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07335536 (The Efficacy of Remimazolam on Incidence of Hypoxia During Sedated Transvaginal Oocyte Retrieval), which is not on this map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07335536 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Efficacy of Remimazolam on Incidence of Hypoxia During Sedated Transvaginal Oocyte Retrieval: A Multicenter Randomized Controlled Trial.

TypeinterventionalSponsorDiansan SuRan2025 to 2026Enrolled400ConditionsHypoxia, Infertility, Infertility Assisted Reproductive TechnologyArmsremimazolam-alfentanil combination, propofol-alfentanil
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. RemimazolamPeerJ · 2026
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  15. Clinical Application Study of Different Doses of Remimazolam Combined With Sevoflurane in Pediatric Adenoidectomy.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fan ZhangDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.ORCID 0000-0002-1256-3818
Huan ChangDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Wenxiang QingDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Rili YuDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Qin LiaoDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.ORCID 0000-0002-9822-7777
Jianbin TongDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Propofol is widely used for sedation of hysteroscopy. It can cause injection pain, respiratory depression, and hypotension. Remimazolam is a novel ultra-short-acting benzodiazepine. Clinical practice has found that the use of remimazolam alone often leads to body movement during hysteroscopy, which decreases the safety and comfort. Here this study is to investigate whether remimazolam combined with low-dose propofol can improve the sedation effect and safety of hysteroscopy. Patients and Methods: In this prospective, randomized, parallel-controlled trial, women (18 to 60 years) undergoing hysteroscopy were randomly assigned to receive propofol (Group P), remimazolam tosylate (Group R), or remimazolam tosylate plus propofol (Group RP). Intraoperative sedation depth was kept at the bispectral index (BIS) value of 40-60. 6 μg/kg alfentanil was used for analgesic before sedation. Intraoperative low pulse oxygen saturation (SpO Results: From February to July 2022, 193 patients were recruited and randomly assigned to group P (n=64), group R (n=64), or group RP (n=65). There was no significant inter-group difference of the intraoperative BIS values. The incidence of low SpO Conclusion: Remimazolam tosylate combined with low dose of propofol improved sedation and safety in hysteroscopy, and may be a more ideal sedative method for hysteroscopy.

Indexed as

HypotensionPropofolBenzodiazepinesDizzinessFemaleHumansHypnotics and SedativesHysteroscopyNauseaPainPregnancyProspective StudiesVomitingBenzodiazepinesHypnotics and SedativesPropofolremimazolamhysteroscopypropofolremimazolam tosylatesedation

Identifiers

PMID36471692
PMCPMC9719264
OpenAlexW4310110482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.