ArticleDeutsches Arzteblatt international2023
The Rising Incidence of Early-Onset Colorectal Cancer.
Article in Deutsches Arzteblatt international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Construction of the survival nomograms for colon cancer patients of different ages based on the SEER database.Journal of cancer research and clinical oncology · 2023Trial
- Incidence Trends of Early-Onset Colorectal Cancer in Germany: A Registry-Based Study From 2003 to 2023.International journal of cancer · 2026Article
- [Prevention and early detection of colorectal cancer].Innere Medizin (Heidelberg, Germany) · 2026Article
- Clinicopathological, prognostic, and molecular differences between microsatellite-stable colorectal cancer patients aged ≤ 30 years and > 30 years.BMC cancer · 2026Article
- Management of Metastatic Colorectal Cancer in Pregnancy: A Systematic Review of a Multidisciplinary Challenge.Visceral medicine · 2026Review
- Global, regional and national burden of colorectal cancer attributable to low-fiber diet from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.Frontiers in nutrition · 2026Article
- Trends and projections in cause-specific mortality among patients with colorectal cancer in the United States, 1999-2040.Frontiers in public health · 2026Article
- Colonoscopy Versus Fecal Occult Blood Test Versus No Screening: A Comparative Analysis of Long-Term Effects.Deutsches Arzteblatt international · 2026Observational
- Changing patterns of colorectal cancer in China between 2000 and 2016 based on tertiary hospital data.Discover oncology · 2025Article
- Caveats of assessing incidence trends using publicly available registry data.European journal of epidemiology · 2025Article
- The Epidemiology of Cervical Cancer in Germany: A Registry-Based Analysis of Incidence, Survival, and Tumor Characteristics (2003–2021).Deutsches Arzteblatt international · 2025Observational
- Actual and Perceived Risk of Colorectal Neoplasia in First-Degree Relatives of Patients with Colorectal Cancer.Clinical and translational gastroenterology · 2025Article
- Fecal Occult Blood Tests for Colorectal Cancer Screening in Routine Medical Care: A Longitudinal Analysis From Germany.Deutsches Arzteblatt international · 2025Article
- [Early-onset colorectal cancer : When should we start with screening?]Radiologie (Heidelberg, Germany) · 2025Review
- Clinical Features in Patients With Early-Onset Colorectal Cancer: An Evaluation of Data From the StuDoQ Database.Deutsches Arzteblatt international · 2025Article
- Evaluating the risk of comorbidity onset in elderly patients after a cancer diagnosis.BMC public health · 2025Article
- Enhanced diagnostic accuracy of SINE-EUS compared to standard EUS in early colorectal cancer: a self-controlled study.International journal of colorectal disease · 2025Article
- Evaluating the necessity of colonoscopy in patients under 40 with rectal bleeding: insights from a large-scale retrospective analysis.International journal of colorectal disease · 2024Observational
- Long-Term Effects on Gonadal Function After Treatment of Colorectal Cancer: A Systematic Review and Meta-Analysis.Cancers · 2024Review
- The Recurrence Rate of Colorectal Polyps among Patients with Average Risk of Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of early-onset (diagnosis before age 50) colorectal cancer (EOCRC) is increasing in some high-income countries. In this study, we examined the trends in EO-CRC incidence in Germany.
methodsWe obtained data on CRC (ICD-10 C18-C20) incidence from the Centre for Cancer Registry Data (excluding cases reported via death certificate only) and on mortality from the official cause of death statistics for 1999-2018 from registries with sufficient incidence coverage. To assess time trends for persons aged 20-49 we calculated the average annual percent changes (AAPC) and corresponding 95% confidence intervals (95% CI). The incidence analyses were stratified by sex, site (proximal colon, distal colon, rectum), age group (20-29, 30-39, and 40-49) and tumor size (T).
resultsEO-CRC accounted for 5.1% (9529 cases) of all colorectal cancers in the selected German regions. The EO-CRC incidence rose annually by 1.16% (95% CI: [0.51; 1.81]) in men and 1.32% [0.80; 1.84] in women. The incidence of proximal colon cancer increased in both sexes (men: AAPC = 3.26 [2.00; 4.53]; women: AAPC = 2.99 [2.17; 3.83]), while the incidence of distal colon cancer remained unchanged.
conclusionThe incidence of EO-CRC in Germany is rising. The reasons are probably multifactorial, reflecting the changing prevalence of early life exposure to risk and protective factors.
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