Evidence map›Paper›PMID 36471454›Full record

ReviewBiomaterials research2022

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies.

Jiale Dong, Wenzhi Wang, Wei Zhou, Siming Zhang, Meng Li, Ning Li, Guoqing Pan, Xianzuo Zhang, Jiaxiang Bai, Chen Zhu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomaterials research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jiale Dong *Department of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, 230001, Hefei, Anhui, P. R. China.
Wenzhi Wang *Department of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, 230001, Hefei, Anhui, P. R. China.
Wei Zhou *Department of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, 230001, Hefei, Anhui, P. R. China.
Siming ZhangDepartment of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, 230001, Hefei, Anhui, P. R. China.
Meng LiDepartment of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, 230001, Hefei, Anhui, P. R. China.
Ning LiDepartment of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, 230001, Hefei, Anhui, P. R. China.
Guoqing PanInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 212013, Zhenjiang, China.
Xianzuo ZhangDepartment of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, 230001, Hefei, Anhui, P. R. China. zhuchena@ustc.edu.cn.
Jiaxiang BaiMedical College, Soochow University, 215006, Suzhou, Jiangsu, P. R. China. jxbai1995@163.com.
Chen ZhuDepartment of Orthopedic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, 230001, Hefei, Anhui, P. R. China. zhuchena@ustc.edu.cn.ORCID http://orcid.org/0000-0002-6432-7745
University of Science and Technology of China · CNJiangsu University · CNSoochow University · CN

Funding

Anhui Provincial Key Research and Development Plan 202004j07020013 and 2022e07020017Anhui Provincial Postdoctoral Science Foundation 2019 B302Fundamental Research Funds for the Central Universities WK9110000173National Natural Science Foundation of China 82272512, 82202672 and 81871788Natural Science Foundation of Anhui Province 2108085QH319Outstanding Youth Fund of Natural Science Foundation of Anhui Province 2108085J41Scientific Research Foundation of Education Department of Anhui Province of China 2020jyxm2316
6 · The paper itself

Abstract

Implant-associated infection (IAI) is increasingly emerging as a serious threat with the massive application of biomaterials. Bacteria attached to the surface of implants are often difficult to remove and exhibit high resistance to bactericides. In the quest for novel antimicrobial strategies, conventional antimicrobial materials often fail to exert their function because they tend to focus on direct bactericidal activity while neglecting the modulation of immune systems. The inflammatory response induced by host immune cells was thought to be a detrimental force impeding wound healing. However, the immune system has recently received increasing attention as a vital player in the host's defense against infection. Anti-infective strategies based on the modulation of host immune defenses are emerging as a field of interest. This review explains the importance of the immune system in combating infections and describes current advanced immune-enhanced anti-infection strategies. First, the characteristics of traditional/conventional implant biomaterials and the reasons for the difficulty of bacterial clearance in IAI were reviewed. Second, the importance of immune cells in the battle against bacteria is elucidated. Then, we discuss how to design biomaterials that activate the defense function of immune cells to enhance the antimicrobial potential. Based on the key premise of restoring proper host-protective immunity, varying advanced immune-enhanced antimicrobial strategies were discussed. Finally, current issues and perspectives in this field were offered. This review will provide scientific guidance to enhance the development of advanced anti-infective biomaterials.

Indexed as

Antibacterial therapeutic strategiesBiomaterialsImmune modulationImplant-associated infections

Identifiers

PMID36471454
PMCPMC9721013
OpenAlexW4310679595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.