ArticleTrials2022
Personalised rehabilitation to improve return to work in patients with persistent spinal pain syndrome type II after spinal cord stimulation implantation: a study protocol for a 12-month randomised controlled trial-the OPERA study.
Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05269212 (Objectifying Performance Assessments and Personalized Rehabilitation Trajectories to Improve Return to Work in Patients With Persistent Spinal Pain Syndrome Type II), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Objectifying Performance Assessments and Personalized Rehabilitation Trajectories to Improve Return to Work in Patients With Persistent Spinal Pain Syndrome Type II: a Randomized Controlled Trial.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does rehabilitation improve work participation in patients with chronic spinal pain after spinal surgery: a systematic review.Journal of rehabilitation medicine · 2025Pooled it
- Experiences of Rehabilitation Professionals in Guiding Rehabilitation for People with Persistent Spinal Pain Syndrome Type 2: A Qualitative Study.Journal of occupational rehabilitation · 2026Article
- Safety of combined exercise and spinal cord stimulation therapy in persistent spinal pain syndrome: a case report.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Patient-Centered Chronic Spinal Pain Management Using Exercise and Neuromodulation: Study Protocol for a Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- Patient-Reported Experience Measures (PREMs) in patients with metastatic colorectal cancer undergoing treatment supported by feedback auditing: the EPIC study.ESMO gastrointestinal oncology · 2025Article
- Global trends and research landscape of arthroscopic therapy and exercise rehabilitation in meniscal tear: a bibliometric analysis.Journal of orthopaedic surgery and research · 2025Article
- Multifidus Fat Infiltration in Patients with Persistent Spinal Pain Syndrome Type II Treated with Spinal Cord Stimulation: A Preliminary Report.Journal of clinical medicine · 2025Article
- Personalized Approaches to Spine Surgery.International journal of spine surgery · 2024Article
- Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review.Journal of clinical medicine · 2024Review
- Synergistic neuromodulation therapy for persistent spinal pain: a proof-of-concept trial on the use of spinal cord and dorsal root ganglion stimulation.Acta neurologica Belgica · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundFor patients with therapy-refractory persistent spinal pain syndrome type II (PSPS-T2), spinal cord stimulation (SCS) may serve as an effective minimally invasive treatment. Despite the evidence that SCS can improve return to work (RTW), only 9.5 to 14% of patients implanted with SCS are effectively capable of returning to work. Thus, it seems that current post-operative interventions are not effective for achieving RTW after SCS implantation in clinical practice. The current objective is to examine whether a personalised biopsychosocial rehabilitation programme specifically targeting RTW alters the work ability in PSPS-T2 patients after SCS implantation compared to usual care.
methodsA two-arm, parallel-group multicentre randomised controlled trial will be conducted including 112 patients who will be randomised (1:1) to either (a) a personalised biopsychosocial RTW rehabilitation programme of 14 weeks or (b) a usual care arm, both with a follow-up period until 12 months after the intervention. The primary outcome is work ability. The secondary outcomes are work status and participation, pain intensity, health-related quality of life, physical activity and functional disability, functional capacities, sleep quality, kinesiophobia, self-management, anxiety, depression and healthcare expenditure. DISCUSSION: Within the OPERA project, we propose a multidisciplinary personalised biopsychosocial rehabilitation programme specifically targeting RTW for patients implanted with SCS, to tackle the high socio-economic burden of patients that are not re-entering the labour market. The awareness is growing that the burden of PSPS-T2 on our society is expected to increase over time due to the annual increase of spinal surgeries. However, innovative and methodologically rigorous trials exploring the potential to decrease the socio-economic burden when patients initiate a trajectory with SCS are essentially lacking.
trial registrationClinicalTrials.gov NCT05269212. Registered on 7 March 2022.
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