Evidence map›Paper›PMID 36471201›Full record

ArticleJournal of assisted reproduction and genetics2023

CircSTAM inhibits migration and invasion of trophoblast cells by regulating miR-148a-5p/PTEN axis.

Lingfeng Chen, Jinyu Yan, Haiyan Zhang, Jia Xu, Xiaopei Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lingfeng ChenDepartment of Obstetrics and Gynecology, The First People's Hospital of Wenling, No. 333, Chuan'an South Road, Chengxi Street, Wenling City, 317500, Zhejiang Province, China.
Jinyu YanDepartment of Obstetrics and Gynecology, The First People's Hospital of Wenling, No. 333, Chuan'an South Road, Chengxi Street, Wenling City, 317500, Zhejiang Province, China.
Haiyan ZhangDepartment of Obstetrics and Gynecology, The First People's Hospital of Wenling, No. 333, Chuan'an South Road, Chengxi Street, Wenling City, 317500, Zhejiang Province, China.
Jia XuDepartment of Obstetrics and Gynecology, The First People's Hospital of Wenling, No. 333, Chuan'an South Road, Chengxi Street, Wenling City, 317500, Zhejiang Province, China.
Xiaopei ChenDepartment of Obstetrics and Gynecology, The First People's Hospital of Wenling, No. 333, Chuan'an South Road, Chengxi Street, Wenling City, 317500, Zhejiang Province, China. bhhk124@163.com.ORCID http://orcid.org/0000-0002-1506-095X
The First People's Hospital of Wenling · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mechanisms underlying the pathogenesis of preeclampsia (PE) remains unclear. Exploring the molecular players in PE progression can provide insights into targeted therapy.

methodsThe expression levels of circSTAM in placental chorionic tissues of PE patients and normal pregnant women were compared by RT-qPCR. CircSTAM was knocked down by small interfering RNA to investigate its role in migration, invasion and epithelial-mesenchymal transformation (EMT) of trophoblast HTR-8/SVneo cells. The downstream target of circSTAM was predicted using online bioinformatics resources, and their molecular interaction was examined by luciferase reporter assay.

resultsCircSTAM was upregulated in PE placenta tissues in comparison to normal placental tissues. CircSTAM knockdown significantly enhanced cellular invasion, migration, as well as EMT. Mir-148a-5p was identified as a target of circSTAM to regulate cell migration and invasion. Mir-148a-5p negatively regulated PTEN expression in trophoblast HTR-8 /SVneo cells.

conclusionIn summary, circSTAM upregulation in PE trophoblasts promoted the invasion, migration and EMT. CircSTAM may modulate trophoblast phenotype by impinging on mir-148a-5p/PTEN axis. These data provided novel insights into the pathogenesis of PE.

Indexed as

MicroRNAsPre-EclampsiaCell ProliferationFemaleHumansPlacentaPregnancyPTEN PhosphohydrolaseRNA, Small InterferingTrophoblastsUp-RegulationMicroRNAsMIRN148 microRNA, humanPTEN PhosphohydrolasePTEN protein, humanRNA, Small InterferingCircSTAMMigrationMiR-148a-5pPreeclampsiaPTEN

Identifiers

PMID36471201
PMCPMC9840740
OpenAlexW4310778984

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.