Evidence map›Paper›PMID 36471093›Full record

ArticleScientific reports2022

Chest x-ray imaging score is associated with severity of COVID-19 pneumonia: the MBrixia score.

Christian M Jensen, Junia C Costa, Jens C Nørgaard, Adrian G Zucco, Bastian Neesgaard, Carsten U Niemann, Sisse R Ostrowski, Joanne Reekie, Birgit Holten, Anna Kalhauge and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Christian M JensenCentre of Excellence for Health, Immunity and Infections (CHIP), Section 2100, , Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark. christian.moeller.jensen@regionh.dk.ORCID 0000-0002-0873-4127
Junia C CostaDepartment of Diagnostic Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jens C NørgaardCentre of Excellence for Health, Immunity and Infections (CHIP), Section 2100, , Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
Adrian G ZuccoCentre of Excellence for Health, Immunity and Infections (CHIP), Section 2100, , Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
Bastian NeesgaardCentre of Excellence for Health, Immunity and Infections (CHIP), Section 2100, , Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
Carsten U NiemannDepartment of Haematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-9880-5242
Sisse R OstrowskiDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5288-3851
Joanne ReekieCentre of Excellence for Health, Immunity and Infections (CHIP), Section 2100, , Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
Birgit HoltenDepartment of Diagnostic Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Anna KalhaugeDepartment of Diagnostic Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Michael A MatthayDepartments of Medicine and Anaesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID 0000-0003-3039-8155
Jens D LundgrenCentre of Excellence for Health, Immunity and Infections (CHIP), Section 2100, , Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.ORCID 0000-0001-8901-7850
Marie HellebergCentre of Excellence for Health, Immunity and Infections (CHIP), Section 2100, , Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
Kasper S MoestrupCentre of Excellence for Health, Immunity and Infections (CHIP), Section 2100, , Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
University of Copenhagen · DKUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatial resolution in existing chest x-ray (CXR)-based scoring systems for coronavirus disease 2019 (COVID-19) pneumonia is low, and should be increased for better representation of anatomy, and severity of lung involvement. An existing CXR-based system, the Brixia score, was modified to increase the spatial resolution, creating the MBrixia score. The MBrixia score is the sum, of a rule-based quantification of CXR severity on a scale of 0 to 3 in 12 anatomical zones in the lungs. The MBrixia score was applied to CXR images from COVID-19 patients at a single tertiary hospital in the period May 4th-June 5th, 2020. The relationship between MBrixia score, and level of respiratory support at the time of performed CXR imaging was investigated. 37 hospitalized COVID-19 patients with 290 CXRs were identified, 22 (59.5%) were admitted to the intensive care unit and 10 (27%) died during follow-up. In a Poisson regression using all 290 MBrixia scored CXRs, a higher MBrixia score was associated with a higher level of respiratory support at the time of performed CXR. The MBrixia score could potentially be valuable as a quantitative surrogate measurement of COVID-19 pneumonia severity, and future studies should investigate the score's validity and capabilities of predicting clinical outcomes.

Indexed as

COVID-19HumansRadiography, ThoracicRetrospective StudiesSARS-CoV-2X-Rays

Identifiers

PMID36471093
PMCPMC9722655
OpenAlexW4310773813

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.