Evidence map›Paper›PMID 36471046›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023

Prediction of extranodal extension in oropharyngeal cancer patients and carcinoma of unknown primary: value of metabolic tumor imaging with hybrid PET compared with MRI and CT.

Amina Nemmour, Thomas M Stadler, Alexander Maurer, Zsofia Kovacs, Bettina Serrallach, Diana Born, Constanze M Nemes, Martina A Broglie, Shila Pazahr, Niels J Rupp and 3 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Upfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV+ OPSCC.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Amina NemmourDepartment of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, Rorschachertrasse 95, 9007, St. Gallen, Switzerland.
Thomas M StadlerDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
Alexander MaurerDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Zsofia KovacsDepartment of Nuclear Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Bettina SerrallachDepartment of Radiology and Nuclear Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Diana BornDepartment of Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Constanze M NemesDepartment of Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Martina A BroglieDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
Shila PazahrDepartment of Neuroradiology, University Hospital Zurich, Zurich, Switzerland.
Niels J RuppDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Martin W HüllnerDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Sandro J StoeckliDepartment of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, Rorschachertrasse 95, 9007, St. Gallen, Switzerland. sandro.stoeckli@kssg.ch.
Grégoire B MorandDepartment of Otorhinolaryngology-Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-6150-6772
Kantonsspital St. Gallen · CHUniversity Hospital of Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the value of metabolic tumor imaging using hybrid PET for the preoperative detection of extranodal extension (ENE) in lymph node metastases of oropharyngeal squamous cell carcinoma (OPSCC).

methodsWe performed a retrospective analysis of a consecutive cohort of patients with OPSCC treated with primary surgery with or without adjuvant (chemo-) radiotherapy at the Kantonsspital Sankt-Gallen and the University Hospital Zurich, Switzerland, from 2010 until 2019. Hybrid PET was compared to conventional cross-sectional imaging with MRI and CT. Histopathological presence of ENE of neck dissection specimen served as gold standard.

resultsA total number of 234 patients were included in the study, 95 (40.6%) of which had pathological ENE (pENE). CT has a good specificity with 93.7%; meanwhile, MRI was the most sensitive diagnostic method (72.0%). The nodal metabolic tumor parameters (SUV

conclusionsCT achieved the best specificity, while MRI had the best sensitivity to detect ENE. Nodal metabolic tumor parameters differed significantly between ENE-positive/negative and p16-positive/negative patients. Hence, quantitative data obtained by metabolic imaging might predict presence of ENE and, therefore, could be helpful in customizing therapy management.

Indexed as

Head and Neck NeoplasmsNeoplasms, Unknown PrimaryOropharyngeal NeoplasmsExtranodal ExtensionFluorodeoxyglucose F18HumansMagnetic Resonance ImagingPositron-Emission TomographyPositron Emission Tomography Computed TomographyPrognosisRetrospective StudiesSquamous Cell Carcinoma of Head and NeckTomography, X-Ray ComputedFluorodeoxyglucose F18BiomarkersComputed tomographyExtranodal extensionHead and neck cancerHuman papillomavirusMagnetic resonance imagingOropharynxPositron emission tomographySquamous cell carcinomaUnknown primary

Identifiers

PMID36471046
OpenAlexW4310784306

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.