ArticleEuropean journal of nuclear medicine and molecular imaging2023
Different z-score cut-offs for striatal binding ratio (SBR) of DaT SPECT are needed to support the diagnosis of Parkinson's Disease (PD) and dementia with Lewy bodies (DLB).
Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Diagnostic performance of molecular imaging methods in predicting the progression from mild cognitive impairment to dementia: an updated systematic review.European journal of nuclear medicine and molecular imaging · 2024Pooled it
- [Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Presynaptic dopaminergic imaging as a neurodegeneration staging biomarker in the alpha-synucleinopathy continuum.European journal of nuclear medicine and molecular imaging · 2026Article
- Visual DAT-SPECT Outperforms Semiquantitative Analysis in a "Pseudo-SWEDD" Case of Benign Tremulous Parkinsonism.Movement disorders clinical practice · 2026Article
- Contribution of quantitative I-123-ioflupane SPECT/CT to the differential diagnosis of dementia with lewy bodies.European journal of nuclear medicine and molecular imaging · 2026Article
- Optimization of Image Quality in Pelvis Lymphoscintigraphy SPECT/CT Using Discovery NM/CT 670.World journal of nuclear medicine · 2025Article
- Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies.Scientific reports · 2025Article
- Neurophysiological markers of motor compensatory mechanisms in early Parkinson's disease.Brain : a journal of neurology · 2024Article
- Optimal DaTQUANT Thresholds for Diagnostic Accuracy of Dementia with Lewy Bodies (DLB) and Parkinson's Disease (PD).Tomography (Ann Arbor, Mich.) · 2024Article
- Neuroimaging biomarkers in the biological definition of Parkinson's disease and dementia with Lewy bodies - EANM position on current state, unmet needs and future perspectives.European journal of nuclear medicine and molecular imaging · 2024Article
- Correction of multiplexing artefacts in multi-pinhole SPECT through temporal shuttering, de-multiplexing of projections, and alternating reconstruction.Physics in medicine and biology · 2024Article
- Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.Annals of neurology · 2024Article
- Effects of medication on dopamine transporter imaging using [European journal of nuclear medicine and molecular imaging · 2024Article
- Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission.European journal of nuclear medicine and molecular imaging · 2024Article
- Odor identification score as an alternative method for early identification of amyloidogenesis in Alzheimer's disease.Scientific reports · 2024Article
- Imaging Biomarkers in Prodromal and Earliest Phases of Parkinson's Disease.Journal of Parkinson's disease · 2024Review
- Morphological characteristics differentiate dementia with Lewy bodies from Parkinson disease with and without dementia.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Longitudinal changes in dopamine transporter uptake scans in progressive apraxia of speech.Clinical parkinsonism & related disorders · 2023Article
- Marked Decreased Tracer Binding in 123 I-FP-CIT SPECT Scans From Lisdexafetamine Dismesylate Interaction: A Case Report.Clinical neuropharmacologyArticle
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15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA cut-off of -2 z-score for striatal or putaminal SBR has been to date arbitrarily used to define an abnormal DaT SPECT in patients with suspected neurodegenerative parkinsonism. We aimed to experimentally identify the most accurate z-score cut-offs for SBR of striatal and substriatal regions to independently discriminate PD and DLB, with respect to essential tremor (ET) and Alzheimer's disease (AD) respectively.
methodsTwo-hundred twenty-five patients undergoing DaT SPECT were enrolled (seventy-five de novo PD, eighty ET, fifty DLB, and twenty AD). Semiquantification was computed by means of Datquant® software which returns measures of striatal SBR and z-scores with respect to 118 healthy volunteers belonging to the Parkinson's Progression Markers Initiative (PPMI). ROC analysis was used to identify most accurate cut-offs for z-score for striatum and substriatal regions (clinical diagnosis at follow-up as gold standard).
resultsPosterior putamen of the most affected hemisphere (MAH) with a z-score cut-off of - 1.27 demonstrated the highest accuracy to differentiate between PD and ET (sensitivity 0.97, specificity 0.94). The whole putamen (z-score cut-off - 0.96) was the most accurate parameter to support the diagnosis of DLB (sensitivity 0.74, specificity 0.95). Putamen to caudate ratio was accurate to detect PD (especially in early stages) while not DLB patients.
conclusionWe experimentally demonstrated that different substriatal regions and cut-offs for z-score of SBR should be considered to support the diagnosis of either PD or DLB. The identified less conservative cut-offs showed higher sensitivity without a measurable reduction in specificity with respect to the arbitrary - 2 z-score.
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