Quantifying Agglomerate-to-Wall Impaction in Dry Powder Inhalers.

Athiya Azeem, Gajendra Singh, Lunjian Li, Hak-Kim Chan, Runyu Yang, Shaokoon Cheng, Agisilaos Kourmatzis

Abstract read

In one paragraph

Article in Pharmaceutical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Athiya AzeemSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.

Gajendra SinghSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.

Lunjian LiSchool of Materials Science and Engineering, UNSW Sydney, Sydney, NSW, 2052, Australia.

Hak-Kim ChanSchool of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia.

Runyu YangSchool of Materials Science and Engineering, UNSW Sydney, Sydney, NSW, 2052, Australia.

Shaokoon ChengSchool of Engineering, Macquarie University, Sydney, NSW, 2109, Australia.

Agisilaos KourmatzisSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, 2006, Australia. agisilaos.kourmatzis@sydney.edu.au.

Funding

Australian Research Council LP190100842

6 · The paper itself

Abstract

purposeThe probability of agglomerate-to-wall collision was quantified using a unique image processing technique applied to high-speed microscopic images. The study aimed to investigate the effects of flow rate and particle size on the percentage of colliding agglomerates detected within an in-house powder dispersion device.

methodThe device consists of a swirl chamber and two tangential inlets in various configurations, designed to emulate the geometric features of commercial devices such as the Aerolizer® and Osmohaler®. The test cases were conducted with constant flow rates of 30 SLPM and 60 SLPM. Four powder samples were tested, including carrier Respitose® SV010 (median volume diameter 104 µm, span 1.7) and mannitol of three constituent primary particle sizes (3 µm, 5 µm and 7 µm; span 1.6 - 1.9).

resultsAt the lower flow rate of 30 SLPM, collision frequencies were significantly different between powders of different constituent particle sizes, but the effects of powder properties diminished on increasing the flow rate to 60 SLPM. At the higher flow rate, all powders experienced a significant increase in the proportion of colliding particles.

conclusionAnalysis of collision events showed that the probability of collision for each agglomerate increased with agglomerate diameter and velocity. Experimental data of agglomerate-to-wall collision were utilised to develop a logistic regression model that can accurately predict collisions with various powders and flow rates.

Indexed as

Dry Powder InhalersMannitolAdministration, InhalationAerosolsParticle SizePowdersAerosolsMannitolPowdersdispersion mechanismsdry powder inhalershigh-speed imaging

Identifiers

PMID36471024

DOI10.1088/1361-6501/aa5525

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.