Evidence map›Paper›PMID 36470898›Full record

ArticleNature communications2022

Federated learning enables big data for rare cancer boundary detection.

Sarthak Pati, Ujjwal Baid, Brandon Edwards, Micah Sheller, Shih-Han Wang, G Anthony Reina, Patrick Foley, Alexey Gruzdev, Deepthi Karkada, Christos Davatzikos and 269 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 176 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  9. Review
  10. Obstacles and Trials in Treating Primary Brain Tumors.International journal of molecular sciences · 2026
    Review
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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

279 authors.

Sarthak Pati *Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2243-8487
Ujjwal Baid *Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5246-2088
Brandon Edwards *Intel Corporation, Santa Clara, CA, USA.ORCID http://orcid.org/0000-0002-0957-9149
Micah ShellerIntel Corporation, Santa Clara, CA, USA.
Shih-Han WangIntel Corporation, Santa Clara, CA, USA.
G Anthony ReinaIntel Corporation, Santa Clara, CA, USA.
Patrick FoleyIntel Corporation, Santa Clara, CA, USA.ORCID http://orcid.org/0000-0001-9401-3088
Alexey GruzdevIntel Corporation, Santa Clara, CA, USA.
Deepthi KarkadaIntel Corporation, Santa Clara, CA, USA.ORCID http://orcid.org/0000-0002-0623-548X
Christos DavatzikosCenter for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1025-8561
Chiharu SakoCenter for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3243-3954
Satyam GhodasaraDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5332-3132
Michel BilelloCenter for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.
Suyash MohanCenter for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4025-115X
Philipp VollmuthDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6224-0064
Gianluca BrugnaraDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2461-1407
Chandrakanth J PreethaDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9875-1982
Felix SahmClinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5441-1962
Klaus Maier-HeinDivision of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6626-2463
Maximilian ZenkDivision of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8933-5995
Martin BendszusDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Wolfgang WickClinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6171-634X
Evan CalabreseDepartment of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1464-0354
Jeffrey RudieDepartment of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8609-8421
Javier Villanueva-MeyerDepartment of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Soonmee ChaDepartment of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Madhura IngalhalikarSymbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, Maharashtra, India.
Manali JadhavSymbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, Maharashtra, India.ORCID http://orcid.org/0000-0002-0561-7144
Umang PandeySymbiosis Center for Medical Image Analysis, Symbiosis International University, Pune, Maharashtra, India.ORCID http://orcid.org/0000-0003-3289-0901
Jitender SainiDepartment of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
John GarrettDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID http://orcid.org/0000-0002-8152-736X
Matthew LarsonDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Robert JerajDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Stuart CurrieLeeds Teaching Hospitals Trust, Department of Radiology, Leeds, UK.ORCID http://orcid.org/0000-0002-0154-6588
Russell FroodLeeds Teaching Hospitals Trust, Department of Radiology, Leeds, UK.ORCID http://orcid.org/0000-0003-2681-9922
Kavi FataniaLeeds Teaching Hospitals Trust, Department of Radiology, Leeds, UK.ORCID http://orcid.org/0000-0003-2421-1083
Raymond Y HuangDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ken ChangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Carmen BalañaCatalan Institute of Oncology, Badalona, Spain.ORCID http://orcid.org/0000-0003-0771-0390
Jaume CapelladesConsorci MAR Parc de Salut de Barcelona, Catalonia, Spain.
Josep PuigDepartment of Radiology (IDI), Girona Biomedical Research Institute (IdIBGi), Josep Trueta University Hospital, Girona, Spain.
Johannes TrenklerInstitute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.ORCID http://orcid.org/0000-0001-6060-4234
Josef PichlerDepartment of Neurooncology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.
Georg NeckerInstitute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.ORCID http://orcid.org/0000-0001-8069-664X
Andreas HaunschmidtInstitute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.ORCID http://orcid.org/0000-0001-9864-5189
Stephan MeckelInstitute of Neuroradiology, Neuromed Campus (NMC), Kepler University Hospital Linz, Linz, Austria.ORCID http://orcid.org/0000-0001-6468-4526
Gaurav ShuklaCenter for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA.
Spencer LiemSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Gregory S AlexanderDepartment of Radiation Oncology, University of Maryland, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1907-7828
Joseph LombardoSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Joshua D PalmerDepartment of Radiation Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-3311-0129
Adam E FlandersDepartment of Radiology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Adam P DickerDepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0733-3337
Haris I SairThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5077-0471
Craig K JonesThe Malone Center for Engineering in Healthcare, The Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-0629-3006
Archana VenkataramanDepartment of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2653-5591
Meirui JiangThe Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0003-4228-8420
Tiffany Y SoThe Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0001-8268-0721
Cheng ChenThe Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-6040-6833
Pheng Ann HengThe Chinese University of Hong Kong, Hong Kong, China.
Qi DouThe Chinese University of Hong Kong, Hong Kong, China.
Michal KozubekCentre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0001-7902-589X
Filip LuxCentre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-3707-8157
Jan MichálekCentre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-5591-1894
Petr MatulaCentre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-4125-1597
Miloš KeřkovskýDepartment of Radiology and Nuclear Medicine, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-0587-9897
Tereza KopřivováDepartment of Radiology and Nuclear Medicine, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-3820-2647
Marek DostálDepartment of Radiology and Nuclear Medicine, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-1740-9227
Václav VybíhalDepartment of Neurosurgery, Faculty of Medicine, Masaryk University, Brno, and University Hospital and Czech Republic, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-5154-5591
Michael A VogelbaumDepartment of Neuro Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
J Ross MitchellUniversity of Alberta, Edmonton, AB, Canada.
Joaquim FarinhasDepartment of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-1040-7894
Joseph A MaldjianUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Chandan Ganesh Bangalore YoganandaUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Marco C PinhoUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Divya ReddyUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
James HolcombUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Benjamin C WagnerUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Benjamin M EllingsonUCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Timothy F CloughesyUCLA Neuro-Oncology Program, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CaA, USA.ORCID http://orcid.org/0000-0002-8656-7483
Catalina RaymondUCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Talia OughourlianUCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Akifumi HagiwaraDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Chencai WangDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-0501-3073
Minh-Son ToCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Sargam BhardwajCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Chee ChongSouth Australia Medical Imaging, Flinders Medical Centre, Bedford Park, SA, Australia.
Marc AgzarianSouth Australia Medical Imaging, Flinders Medical Centre, Bedford Park, SA, Australia.ORCID http://orcid.org/0000-0002-2562-0340
Alexandre Xavier FalcãoInstitute of Computing, University of Campinas, Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-2914-5380
Samuel B MartinsFederal Institute of São Paulo, Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-2894-3911
Bernardo C A TeixeiraInstituto de Neurologia de Curitiba, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0003-4769-6562
Flávia SprengerDepartment of Radiology, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0002-1631-3517
David MenottiDepartment of Informatics, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0003-2430-2030
Diego R LucioDepartment of Informatics, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Pamela LaMontagneDepartment of Radiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6752-8518
Daniel MarcusDepartment of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Benedikt WiestlerDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2963-7772
Florian KoflerDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-0642-7884
Ivan EzhovDepartment of Informatics, Technical University of Munich, Munich, Bavaria, Germany.ORCID http://orcid.org/0000-0002-0862-6513
Marie MetzDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-1459-5741
Rajan JainDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-4879-0457
Matthew LeeDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-8816-1076
Yvonne W LuiDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-9984-9164
Richard McKinleySupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-8250-6117
Johannes SlotboomSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-5121-9852
Piotr RadojewskiSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Raphael MeierSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Roland WiestSupport Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-7030-2045
Derrick MurciaDepartment of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
Eric FuDepartment of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
Rourke HaasDepartment of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
John ThompsonDepartment of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
David Ryan OrmondDepartment of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-7027-2915
Chaitra BadveDepartment of Radiology, University Hospitals Cleveland, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-8547-8019
Andrew E SloanDepartment of Neurological Surgery, University Hospitals-Seidman Cancer Center, Cleveland, OH, USA.
Vachan VadmalDepartment of Neurosurgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Kristin WaiteNational Cancer Institute, National Institute of Health, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3186-8510
Rivka R ColenDepartment of Radiology, Neuroradiology Division, University of Pittsburgh, Pittsburgh, PA, USA.
Linmin PeiUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Murat AkDepartment of Radiology, Neuroradiology Division, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7384-478X
Ashok SrinivasanDepartment of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
J Rajiv BapurajDepartment of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3933-203X
Arvind RaoDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Nicholas WangDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9796-4532
Ota YoshiakiDepartment of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
Toshio MoritaniDepartment of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
Sevcan TurkDepartment of Neuroradiology, University of Michigan, Ann Arbor, MI, USA.
Joonsang LeeDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9694-4425
Snehal PrabhudesaiDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Fanny MorónDepartment of Radiology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-3745-2177
Jacob MandelDepartment of Neurology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5916-5668
Konstantinos KamnitsasDepartment of Computing, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-3281-6509
Ben GlockerDepartment of Computing, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-4897-9356
Luke V M DixonDepartment of Radiology, Imperial College NHS Healthcare Trust, London, UK.ORCID http://orcid.org/0000-0003-4060-7897
Matthew WilliamsComputational Oncology Group, Institute for Global Health Innovation, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-7096-0718
Peter ZampakisDepartment of NeuroRadiology, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0002-5104-9619
Vasileios PanagiotopoulosDepartment of Neurosurgery, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0001-9298-2985
Panagiotis TsiganosClinical Radiology Laboratory, Department of Medicine, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0002-3279-4947
Sotiris AlexiouDepartment of Electrical and Computer Engineering, University of Patras, Patras, Greece.
Ilias HaliassosDepartment of Neuro-Oncology, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0002-3278-0588
Evangelia I ZacharakiDepartment of Electrical and Computer Engineering, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0001-8228-0437
Konstantinos MoustakasDepartment of Electrical and Computer Engineering, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0001-7617-227X
Christina KalogeropoulouDepartment of NeuroRadiology, University of Patras, Patras, Greece.ORCID http://orcid.org/0000-0002-9725-1791
Dimitrios M KardamakisDepartment of Radiation Oncology, University of Patras, Patras, Greece.
Yoon Seong ChoiYonsei University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0002-6034-9912
Seung-Koo LeeYonsei University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0001-5646-4072
Jong Hee ChangYonsei University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0003-1509-9800
Sung Soo AhnYonsei University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0002-0503-5558
Bing LuoDepartment of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Laila PoissonPublic Health Sciences, Henry Ford Health System, Detroit, MI, USA.ORCID http://orcid.org/0000-0002-3409-6536
Ning WenDepartment of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.ORCID http://orcid.org/0000-0001-9776-8056
Pallavi TiwariCase Western Reserve University, Cleveland, OH, USA.
Ruchika VermaAlberta Machine Intelligence Institute, Edmonton, AB, Canada.
Rohan BarejaCase Western Reserve University, Cleveland, OH, USA.
Ipsa YadavCase Western Reserve University, Cleveland, OH, USA.
Jonathan ChenCase Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-4907-0061
Neeraj KumarUniversity of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-3221-3831
Marion SmitsDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0001-5563-2871
Sebastian R van der VoortDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Ahmed AlafandiDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Fatih IncekaraDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Maarten M J WijnengaDepartment of Neurology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
Georgios KapsasDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0001-8043-958X
Renske GahrmannDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0001-7384-8633
Joost W SchoutenDepartment of Neurosurgery, Brain Tumor Center, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.
Hendrikus J DubbinkDepartment of Pathology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0002-2160-5207
Arnaud J P E VincentDepartment of Neurosurgery, Brain Tumor Center, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0003-0865-8272
Martin J van den BentDepartment of Neurology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0001-5710-5127
Pim J FrenchDepartment of Neurology, Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0002-0668-9529
Stefan KleinBiomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0003-4449-6784
Yading YuanDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4483-6702
Sonam SharmaDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tzu-Chi TsengDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Saba AdabiDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Simone P NiclouNORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.ORCID http://orcid.org/0000-0002-3417-9534
Olivier KeunenTranslation Radiomics, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.ORCID http://orcid.org/0000-0003-2203-7026
Ann-Christin HauNORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.ORCID http://orcid.org/0000-0002-4412-2355
Martin VallièresDepartment of Computer Science, Université de Sherbrooke, Sherbrooke, QC, Canada.ORCID http://orcid.org/0000-0001-7639-8172
David FortinCentre de Recherche du Centre Hospitalière Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Martin LepageCentre de Recherche du Centre Hospitalière Universitaire de Sherbrooke, Sherbrooke, QC, Canada.ORCID http://orcid.org/0000-0002-5363-9487
Bennett LandmanElectrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5733-2127
Karthik RamadassElectrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Kaiwen XuDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-2664-255X
Silky ChotaiDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Lola B ChamblessDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Akshitkumar MistryDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Reid C ThompsonDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Yuriy GusevInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.ORCID http://orcid.org/0000-0001-7371-4715
Krithika BhuvaneshwarInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.ORCID http://orcid.org/0000-0003-4015-7056
Anousheh SayahDivision of Neuroradiology & Neurointerventional Radiology, Department of Radiology, MedStar Georgetown University Hospital, Washington, DC, USA.ORCID http://orcid.org/0000-0002-9683-3802
Camelia BencheqrounInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.
Anas BeloualiInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.ORCID http://orcid.org/0000-0002-2780-2500
Subha MadhavanInnovation Center for Biomedical Informatics (ICBI), Georgetown University, Washington, DC, USA.
Thomas C BoothSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0984-3998
Alysha ChelliahSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Marc ModatSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Haris ShuaibStoke Mandeville Hospital, Mandeville Road, Aylesbury, UK.ORCID http://orcid.org/0000-0001-6975-5960
Carmen DragosStoke Mandeville Hospital, Mandeville Road, Aylesbury, UK.ORCID http://orcid.org/0000-0002-5391-0310
Aly AbayazeedNeosoma Inc., Groton, MA, USA.
Kenneth KolodziejNeosoma Inc., Groton, MA, USA.
Michael HillNeosoma Inc., Groton, MA, USA.
Ahmed AbbassyUniversity of Cairo School of Medicine, Giza, Egypt.
Shady GamalUniversity of Cairo School of Medicine, Giza, Egypt.
Mahmoud MekhaimarUniversity of Cairo School of Medicine, Giza, Egypt.
Mohamed QayatiUniversity of Cairo School of Medicine, Giza, Egypt.ORCID http://orcid.org/0000-0002-1196-4978
Mauricio ReyesUniversity of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-2434-9990
Ji Eun ParkDepartment of Radiology, Asan Medical Center, Seoul, South Korea.
Jihye YunDepartment of Radiology, Asan Medical Center, Seoul, South Korea.
Ho Sung KimDepartment of Radiology, Asan Medical Center, Seoul, South Korea.ORCID http://orcid.org/0000-0002-9477-7421
Abhishek MahajanThe Clatterbridge Cancer Centre NHS Foundation Trust Pembroke Place, Liverpool, UK.ORCID http://orcid.org/0000-0001-6606-6537
Mark MuziDepartment of Radiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8767-191X
Sean BensonNetherlands Cancer Institute, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0003-4819-779X
Regina G H Beets-TanDepartment of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Jonas TeuwenNetherlands Cancer Institute, Amsterdam, Netherlands.
Alejandro Herrera-TrujilloClínica Imbanaco Grupo Quirón Salud, Cali, Colombia.ORCID http://orcid.org/0000-0002-9775-9405
Maria TrujilloUniversidad del Valle, Cali, Colombia.
William EscobarClínica Imbanaco Grupo Quirón Salud, Cali, Colombia.
Ana AbelloUniversidad del Valle, Cali, Colombia.
Jose BernalUniversidad del Valle, Cali, Colombia.ORCID http://orcid.org/0000-0003-3167-5134
Jhon GómezUniversidad del Valle, Cali, Colombia.
Joseph ChoiDepartment of Industrial and Systems Engineering, University of Iowa, Iowa, USA.
Stephen BaekDepartment of Industrial and Systems Engineering, Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-4758-4539
Yusung KimDepartment of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
Heba IsmaelDepartment of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
Bryan AllenDepartment of Radiation Oncology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-4893-7105
John M BuattiDepartment of Radiation Oncology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-8499-3721
Aikaterini KotrotsouMD Anderson Cancer Center, University of Texas, Houston, TX, USA.
Hongwei LiDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Tobias WeissDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-5533-9429
Michael WellerDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1748-174X
Andrea BinkDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-2163-3400
Bertrand PouymayouDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8060-7827
Hassan F ShaykhUniversity of Alabama in Birmingham, Birmingham, AL, USA.
Joel SaltzDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA.ORCID http://orcid.org/0000-0002-3451-2165
Prateek PrasannaDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA.
Sampurna ShresthaDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA.ORCID http://orcid.org/0000-0001-6753-251X
Kartik M ManiDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA.ORCID http://orcid.org/0000-0002-1193-2925
David PayneDepartment of Radiology, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0000-0002-6316-7911
Tahsin KurcDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA.ORCID http://orcid.org/0000-0001-9237-4306
Enrique PelaezEscuela Superior Politecnica del Litoral, Guayaquil, Guayas, Ecuador.ORCID http://orcid.org/0000-0001-9355-5440
Heydy Franco-MaldonadoSociedad de Lucha Contral el Cancer - SOLCA, Guayaquil Ecuador, Guayaquil, Ecuador.
Francis LoayzaEscuela Superior Politecnica del Litoral, Guayaquil, Guayas, Ecuador.ORCID http://orcid.org/0000-0002-6283-3679
Sebastian QuevedoUniversidad Católica de Cuenca, Cuenca, Ecuador.ORCID http://orcid.org/0000-0001-5585-0270
Pamela GuevaraUniversidad de Concepción, Concepción, Biobío, Chile.ORCID http://orcid.org/0000-0001-9988-400X
Esteban TorcheUniversidad de Concepción, Concepción, Biobío, Chile.
Cristobal MendozaUniversidad de Concepción, Concepción, Biobío, Chile.ORCID http://orcid.org/0000-0002-3718-0629
Franco VeraUniversidad de Concepción, Concepción, Biobío, Chile.
Elvis RíosUniversidad de Concepción, Concepción, Biobío, Chile.ORCID http://orcid.org/0000-0002-0194-9504
Eduardo LópezUniversidad de Concepción, Concepción, Biobío, Chile.ORCID http://orcid.org/0000-0003-3526-5271
Sergio A VelastinSchool of Electronic Engineering and Computer Science, Queen Mary University of London, London, UK.
Godwin OgboleDepartment of Radiology, University College Hospital Ibadan, Oyo, Nigeria.ORCID http://orcid.org/0000-0003-0431-7198
Mayowa SoneyeDepartment of Radiology, University College Hospital Ibadan, Oyo, Nigeria.
Dotun OyekunleDepartment of Radiology, University College Hospital Ibadan, Oyo, Nigeria.ORCID http://orcid.org/0000-0003-3957-0206
Olubunmi Odafe-OyibothaClinix Healthcare, Lagos, Lagos, Nigeria.
Babatunde OsobuDepartment of Radiology, University College Hospital Ibadan, Oyo, Nigeria.
Mustapha Shu'aibuDepartment of Radiology, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria.
Adeleye DorcasDepartment of Radiology, Obafemi Awolowo University Ile-Ife, Ile-Ife, Osun, Nigeria.
Farouk DakoDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4765-9358
Amber L SimpsonDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Mohammad HamghalamSchool of Computing, Queen's University, Kingston, ON, Canada.
Jacob J PeoplesSchool of Computing, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0003-0191-7446
Ricky HuSchool of Computing, Queen's University, Kingston, ON, Canada.
Anh TranSchool of Computing, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0003-4596-3321
Danielle CutlerThe Faculty of Arts & Sciences, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0001-7523-714X
Fabio Y MoraesDepartment of Oncology, Queen's University, Kingston, ON, Canada.ORCID http://orcid.org/0000-0003-3407-9215
Michael A BossCenter for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9492-767X
James GimpelCenter for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4245-9429
Deepak Kattil VeettilCenter for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0317-5477
Kendall SchmidtData Science Institute, American College of Radiology, Reston, VA, USA.
Brian BialeckiData Science Institute, American College of Radiology, Reston, VA, USA.ORCID http://orcid.org/0000-0003-1835-7449
Sailaja MarellaCenter for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Cynthia PriceCenter for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Lisa CiminoCenter for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Charles ApgarCenter for Research and Innovation, American College of Radiology, Philadelphia, PA, USA.
Prashant ShahIntel Corporation, Santa Clara, CA, USA.ORCID http://orcid.org/0000-0003-1055-574X
Bjoern MenzeDepartment of Informatics, Technical University of Munich, Munich, Bavaria, Germany.
Jill S Barnholtz-SloanNational Cancer Institute, National Institute of Health, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6190-9304
Jason MartinIntel Corporation, Santa Clara, CA, USA.ORCID http://orcid.org/0000-0003-2476-7639
Spyridon BakasCenter for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA. sbakas@upenn.edu.ORCID http://orcid.org/0000-0001-8734-6482

Funding

NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
ARRA - ADOPT New Technologies for RDC/CDMSU01CA080098 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI SCHNALL, MITCHELL D. · 1999 to 2011
$182.7M
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6M
RTOG Foreign AccrualU10CA021661 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI CURRAN, WALTER J. · 1985 to 2013
$150.3M
Statistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI James J. Dignam, GREG YOTHERS · 2014 to 2026
$146.4M
Statistics CoreU10CA180794 · NCI · DANA-FARBER CANCER INST · PI PAUL J CATALANO, CONSTANTINE A. GATSONIS · 2014 to 2026
$111.2M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
BIOSTATISTICS DATA MANAGEMENT CENTER FOR ACROINU01CA079778 · NCI · BROWN UNIVERSITY · PI GATSONIS, CONSTANTINE A. · 1999 to 2011
$48.6M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
RTOG Foreign AccrualsU10CA037422 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI BRUNER, DEBORAH WATKINS · 1985 to 2013
$30.4M
MSHS Translational Science HubUL1TR001433 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROSALIND J · 2015 to 2019
$26.6M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
Cancer Research UK 28832Medical Research Council MR/W021684/1NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001433NCI NIH HHS P30 CA051008NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA082500NCI NIH HHS R01 CA233888NCI NIH HHS R01 CA269948NCI NIH HHS R01 CA270027NCI NIH HHS R37 CA214955NCI NIH HHS R50 CA211270NCI NIH HHS U01 CA079778NCI NIH HHS U01 CA080098NCI NIH HHS U01 CA176110NCI NIH HHS U01 CA242871NCI NIH HHS U01 CA248226NCI NIH HHS U10 CA021661NCI NIH HHS U10 CA037422NCI NIH HHS U10 CA079778NCI NIH HHS U10 CA080098NCI NIH HHS U10 CA180794NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868NCI NIH HHS U24 CA189523NCI NIH HHS U24 CA215109NIBIB NIH HHS R21 EB030209NIH HHS S10 OD023495NINDS NIH HHS R01 NS042645NLM NIH HHS R01 LM013151Wellcome Trust
6 · The paper itself

Abstract

Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically targetable tumor, and 23% for the complete tumor extent, over a publicly trained model. We anticipate our study to: 1) enable more healthcare studies informed by large diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further analyses for glioblastoma by releasing our consensus model, and 3) demonstrate the FL effectiveness at such scale and task-complexity as a paradigm shift for multi-site collaborations, alleviating the need for data-sharing.

Indexed as

Big DataGlioblastomaHumansInformation DisseminationMachine LearningRare Diseases

Identifiers

PMID36470898
PMCPMC9722782

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