Evidence map›Paper›PMID 36470837›Full record

ArticleAmerican journal of preventive medicine2023

Cigarette‒E-cigarette Transitions and Respiratory Symptom Development.

Jonathan B Berlowitz, Wubin Xie, Alyssa F Harlow, Michael J Blaha, Aruni Bhatnagar, Emelia J Benjamin, Andrew C Stokes

Open access · hybridAbstract read
In one paragraph

Article in American journal of preventive medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Association of Cigarette-E-Cigarette Transitions With Respiratory Symptom Resolution.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Vaping-Induced Proteolysis Causes Airway Surface Dehydration.International journal of molecular sciences · 2023
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jonathan B BerlowitzFrom the Department of Global Health, Boston University School of Public Health, Boston, Massachusetts; Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Wubin XieFrom the Department of Global Health, Boston University School of Public Health, Boston, Massachusetts.
Alyssa F HarlowDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
Michael J BlahaCiccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Aruni BhatnagarDepartment of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky.
Emelia J BenjaminDepartment of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Andrew C StokesFrom the Department of Global Health, Boston University School of Public Health, Boston, Massachusetts. Electronic address: acstokes@bu.edu.
Boston University · USJohns Hopkins University · USUniversity of Louisville · USUniversity of Southern California · US

Funding

Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1M
ConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8M
Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular HealthK01HL154130 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STOKES, ANDREW · 2020 to 2024
$904k
MEDICAL STUDENT SUMMER RESEARCH PROGRAM IN HEART, LUNG AND BLOOD DISEASES (RPHLB)T35HL139444 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FINE, ALAN FINE, SARFATY, SUZANNE · 2019 to 2023
$479k
NHLBI NIH HHS K01 HL154130NHLBI NIH HHS P50 HL120163NHLBI NIH HHS T35 HL139444NHLBI NIH HHS U54 HL120163
6 · The paper itself

Abstract

introductionE-cigarette use is associated with pulmonary inflammation, functional respiratory changes, and chronic lung disease. Most population-level E-cigarette research has utilized point-in-time measures of E-cigarette exposures, which may not generalize to adults who transition between cigarettes and E-cigarettes.

methodsData obtained from the Population Assessment of Tobacco and Health study were collected from 2013 to 2019 and analyzed in 2022. Three observations were created per respondent, with exposure intervals assessed over Waves 1-2, 2-3, and 3-4. Each wave of the exposure interval was classified as nonuse, exclusive E-cigarette use, exclusive smoking, or dual use, producing 16 possible cigarette‒E-cigarette transitions. The association between transitions and both dry nighttime cough and wheeze symptom development during follow-up were assessed using mixed-effects Poisson models.

resultsAmong 33,231 observations from 13,528 unique participants, transitioning from nonuse to exclusive E-cigarette use was associated with 1.62 times higher incidence rate of wheeze (incident rate ratio=1.62; 95% CI=1.12, 2.34) than persistent nonuse. There was no change in reported dry nighttime cough (incident rate ratio=0.84; 95% CI=0.52, 1.35) or wheeze (incident rate ratio=0.87; 95% CI=0.52, 1.46) in individuals who switched from cigarettes to E-cigarettes, whereas transitioning from dual use to E-cigarette use was associated with large reductions in both symptoms (incident rate ratio=0.58; 95% CI=0.39, 0.87 and incident rate ratio=0.36; 95% CI=0.20, 0.63, respectively).

conclusionsE-cigarette initiation among nonusers is associated with increased respiratory morbidity. Further research should assess the risks and benefits of E-cigarette‒assisted cigarette cessation given the reduction in symptom development rates among dual use to E-cigarette switchers.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsVapingAdultCoughHumansSmoking

Identifiers

PMID36470837
PMCPMC10033326
OpenAlexW4310773009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.