Evidence map›Paper›PMID 36470706›Full record

ArticleTrends in neurosciences2023

Positioning the brainstem within the neural network of threat prediction.

Xu O Zhang, Fabricio H Do Monte

Abstract readComment
In one paragraph

Article in Trends in neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Xu O ZhangDepartment of Neurobiology and Anatomy, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Fabricio H Do MonteDepartment of Neurobiology and Anatomy, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: fabricio.h.domonte@uth.tmc.edu.

Funding

Neural Circuits Balancing Reward-Approaching with Threat-AvoidanceR01MH120136 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DO MONTE, FABRICIO HOFFMANN · 2020 to 2024
$2.8M
Thalamic circuits in the integration of fear and rewardK99MH105549 · NIMH · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI DO MONTE, FABRICIO HOFFMANN · 2015 to 2016
$137k
NIMH NIH HHS K99 MH105549NIMH NIH HHS R01 MH120136
6 · The paper itself

Abstract

In a recent study, Strickland and McDannald dissected the role of brainstem networks in threat prediction. Using probabilistic threat discrimination in rats, the authors demonstrated that brainstem neurons estimate threat probability and generate positive aversive prediction errors after unexpected outcomes. Their findings suggest that, beyond organizing defensive behaviors, brainstem neurons are involved in threat prediction computations.

Indexed as

Brain StemNeuronsAnimalsNeural Networks, ComputerPeriaqueductal GrayRatsassociative learningaversive prediction errordorsal raphe nucleusfear conditioning discriminationperiaqueductal grey matter

Identifiers

PMID36470706
PMCPMC9877175

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.