ArticleNature2023
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 4 pooled it
28.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
165 citing papers in PubMed, 4 syntheses or guidelines pooled it, 288 citations in OpenAlex.
- Clinical effects of ursodeoxycholic acid in COVID-19 infection: a systematic review and dose-response meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions.Frontiers in medicine · 2025Pooled it
- Causal relationship between blood metabolites and risk of five infections: a Mendelian randomization study.BMC infectious diseases · 2023Pooled it
- The gut microbiome-bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases.Gut microbes · 2026Review
- Metabolic control of macrophages in coronavirus disease 2019.Virulence · 2026Review
- Interplay between SFTSV and host innate immunity: Viral evasion mechanisms, pathogenesis, and therapeutic perspectives.iScience · 2026Review
- Article
- Article
- Clinical course, prognostic markers, and transplant implications in COVID-19-associated secondary sclerosing cholangitis.Journal of gastroenterology · 2026Article
- The Applications and Future Prospects of Organ Medicine.Health care science · 2026Article
- Drug Repurposing as a Broad-Spectrum Strategy Against Coronaviruses: Frontiers in Mechanisms and Clinical Translation.Viruses · 2026Review
- Ursodeoxycholic acid and long COVID in steatotic liver disease: a nationwide cohort study.Clinical and molecular hepatology · 2026Article
- Ursodeoxycholic acid inhibits feline infectious peritonitis virus infection through activating JAK-STAT signaling pathway-induced type I interferon.Microbiology spectrum · 2026Article
- The intestinal microbiota as a key modulator of acute graft-versus-host disease.Nature reviews. Cancer · 2026Review
- Ursodeoxycholic acid treatment did not show protective effect for severe COVID-19 outcomes - a nationwide register study.BMC public health · 2026Article
- Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ursodeoxycholic acid inhibits pneumonia caused by PRCV through the activation of TLR4-IRF3 mediated type Ⅰ interferon pathway.Veterinary research · 2026Article
- Discovery of Zidovudine as a cardiomyocyte protectant for doxorubicin-induced toxicity through high-throughput phenotypic drug screening.Fundamental research · 2026Article
- Organoids Gone Viral: A Comprehensive Review on Human Organoid Models to Study Viral Pathogenesis.Viruses · 2026Review
105 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
80 authors at 16 institutions in 8 countries.
Teresa BreviniWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. tb647@cam.ac.uk.ORCID http://orcid.org/0000-0002-3581-5379
Mailis MaesCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0266-6557
Gwilym J WebbCambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Binu V JohnDivision of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA.
Claudia D FuchsHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Gustav BuescherDepartment of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Lu WangTransplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-4418-8602
Chelsea GriffithsTransplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Marnie L BrownTransplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0001-6463-0288
William E ScottTransplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0003-1515-0514
Pehuén Pereyra-GerberCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
William T H GelsonCambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Stephanie BrownWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Scott DillonWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Daniele MuraroWellcome Sanger Institute, Hinxton, UK.
Jo SharpCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-8482-5736
Megan NearyCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-4960-2139
Helen BoxCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Lee TathamCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-9448-8876
James StewartDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-8928-2037
Paul CurleyCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Henry PertinezCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Sally ForrestCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
Petra MlcochovaCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
Sagar S VarankarWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Mahnaz Darvish-DamavandiWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-0226-2621
Victoria L MulcahyAcademic Department of Medical Genetics, University of Cambridge, Cambridge, UK.
Rhoda E KucExperimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Thomas L WilliamsExperimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.ORCID http://orcid.org/0000-0002-1051-0595
James A HeslopWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Davide RossettiWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Olivia C TysoeWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Vasileios GalanakisWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Marta Vila-GonzalezWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Thomas W M CrozierCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0951-4588
Johannes BargehrWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-9304-3573
Sanjay SinhaWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-5900-1209
Sara S UpponiDepartment of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Corrina FearDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Lisa SwiftDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.ORCID http://orcid.org/0000-0002-0633-3696
Susan E DaviesDepartment of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Axel WesterDepartment of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-3634-6591
Hannes HagströmDepartment of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
Espen MelumNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.ORCID http://orcid.org/0000-0001-6903-6878
Darran ClementsWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Peter HumphreysWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
Jo HerriottCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Edyta KijakCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Helen CoxCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Chloe BramwellCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-8274-457X
Anthony ValentijnCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Christopher J R IllingworthMRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
UK-PBC Consortium
Bassam DahmanDepartment of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA.
Dustin R BastaichDepartment of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA.
Raphaella D FerreiraDivision of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA.
Thomas MarjotOxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.
Eleanor BarnesOxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0860-0831
Andrew M MoonDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-7163-2062
Alfred S BarrittDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.
Ravindra K GuptaCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9751-1808
Stephen BakerCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1308-5755
Anthony P DavenportExperimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.ORCID http://orcid.org/0000-0002-2096-3117
Gareth CorbettCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Vassilis G GorgoulisDepartment of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0001-9001-4112
Simon J A BuczackiWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-2975-416X
Joo-Hyeon LeeWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-7364-6422
Nicholas J MathesonCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3318-1851
Michael TraunerHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-1275-6425
Andrew J FisherTransplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0003-4822-7223
Paul GibbsDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Andrew J ButlerDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Christopher J E WatsonDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.ORCID http://orcid.org/0000-0002-0590-4901
George F MellsCambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Gordon DouganCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
Andrew OwenCentre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-9819-7651
Ansgar W LohseDepartment of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Ludovic VallierWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. ludovic.vallier@bih-charite.de.ORCID http://orcid.org/0000-0002-3848-2602
Fotios SampaziotisWellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. fs347@cam.ac.uk.ORCID http://orcid.org/0000-0003-0812-7586
University of Cambridge · GBWellcome/MRC Cambridge Stem Cell Institute · GBUniversity of Liverpool · GBNewcastle University · GBCambridge University Hospitals NHS Foundation Trust · GBUniversity of North Carolina at Chapel Hill · USKarolinska Institutet · SEMedical University of Vienna · ATUniversität Hamburg · DEUniversity of Miami Health System · USUniversity of Oxford · GBVirginia Commonwealth University · USNHS Blood and Transplant · GBOslo University Hospital · NOUniversity of Dundee · GBWellcome Sanger Institute · GB
Funding
British Heart Foundation FS/18/46/33663Medical Research Council MC_PC_17230Medical Research Council MC_PC_19026Medical Research Council MR/L001489/1Medical Research Council MR/P008801/1Medical Research Council MR/V002074/1Wellcome Trust
Abstract
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)
Indexed as
Angiotensin-Converting Enzyme 2COVID-19Receptors, VirusUrsodeoxycholic AcidAnimalsCOVID-19 Drug TreatmentCricetinaeHumansLiverLiver TransplantationLungMiceNasal MucosaOrganoidsPregnenedionesReceptor, Farnesoid X-ActivatedACE2 protein, humanAngiotensin-Converting Enzyme 2pregna-4,17-diene-3,16-dionePregnenedionesReceptor, Farnesoid X-ActivatedReceptors, VirusUrsodeoxycholic Acid
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.