ArticleJournal of psychiatric research2023
Directionality of change in obsessive compulsive disorder and depression over six years of prospective follow-up.
Article in Journal of psychiatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Longitudinal coupling of obsessive-compulsive symptoms with depressive and anxiety symptoms: A cross-domain latent growth curve analysis.Journal of mood and anxiety disorders · 2026Article
- Reducing anxiety and depression in OCD: a randomized controlled trial of exposure and response prevention therapy.Health psychology report · 2026Article
- Network Analysis of Sensory Phenomena and Obsessive-Compulsive Symptoms in OCD: A Multicenter Study.Depression and anxiety · 2026Article
- Unraveling Gender Differences in Obsessive-Compulsive Disorder: A Focus on Key Micronutrients.Cureus · 2025Article
- Gender differences in the relationship between obsessive-compulsive symptoms and suicide risk among psychiatric outpatient adolescents: the role of depressive symptoms, anxiety symptoms, and sleep disturbances.Frontiers in public health · 2025Article
- The bidirectional relationship between severity of obsessive-compulsive symptoms and lifestyle factors in patients with obsessive-compulsive disorder: a contemporaneous and prospective analysis.Frontiers in psychiatry · 2025Article
- Prevalence of Antidepressant Prescription in Adolescents Newly Diagnosed with Depression in Germany.Children (Basel, Switzerland) · 2024Article
- Altered dynamic neural activities in individuals with obsessive-compulsive disorder and comorbid depressive symptoms.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Major Depressive Disorder (MDD) is often comorbid with obsessive-compulsive disorder (OCD) yet little is known about the directionality of the association between OCD and depression symptoms. We aim to investigate the effect OCD symptoms has on depression symptoms and vice versa over an extended period of time. This is one of the first longitudinal studies to evaluate the relationship between OCD and depression in a large clinical sample. Participants (n = 324) were treatment-seeking adults with a primary diagnosis of OCD. OCD and depression symptoms were assessed annually over the six-year follow-up period. Random intercepts cross-lagged panel models (RI-CLPM) were conducted to compare unidirectional and bidirectional models over time. The best-fitting and most parsimonious model included paths with OCD symptoms predicting depression symptoms, but not vice versa. OCD symptom severity in a given year predicted next year depression severity. However, depression severity did not predict next-year OCD symptom severity in this sample. Our results suggest that depression severity may be secondary to OCD symptoms and treating OCD should be prioritized over treating depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.