Evidence map›Paper›PMID 36470166›Full record

ArticleSleep medicine2023

Sleep disturbance is associated with perturbations in immune-inflammatory pathways in oncology outpatients undergoing chemotherapy.

Alejandra Calvo-Schimmel, Kord M Kober, Steven M Paul, Bruce A Cooper, Carolyn Harris, Joosun Shin, Marilyn J Hammer, Yvette P Conley, Vasuda Dokiparthi, Adam Olshen and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Alejandra Calvo-SchimmelDepartment of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: sandra.schimmel@ucsf.edu.
Kord M KoberDepartment of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: kord.kober@ucsf.edu.
Steven M PaulDepartment of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: steven.paul@ucsf.edu.
Bruce A CooperDepartment of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: bruce.cooper@ucsf.edu.
Carolyn HarrisDepartment of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: carolyn.harris@ucsf.edu.
Joosun ShinDepartment of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: joosun.shin@ucsf.edu.
Marilyn J HammerDana Farber Cancer Institute, Boston, MA, USA. Electronic address: marilynj_hammer@dfci.harvard.edu.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: yconley@pitt.edu.
Vasuda DokiparthiDepartment of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: vasudok@gmail.com.
Adam OlshenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Electronic address: adam.olshen@ucsf.edu.
Jon D LevineDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: jon.levine@ucsf.edu.
Christine MiaskowskiDepartment of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: chris.miaskowski@ucsf.edu.
University of California, San Francisco · USDana-Farber Cancer Institute · USUniversity of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics ApproachR37CA233774 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOBER, KORD MICHAEL · 2019 to 2025
$4.8M
Biobehavioral Research Training Program in Symptom ScienceT32NR016920 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A., WEISS, SANDRA JEAN · 2017 to 2021
$2.4M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA134900NCI NIH HHS R37 CA233774NINR NIH HHS T32 NR016920
6 · The paper itself

Abstract

OBJECTIVE/

backgroundSleep disturbance is a common problem in patients receiving chemotherapy. Purpose was to evaluate for perturbations in immune-inflammatory pathways between oncology patients with low versus very high levels of sleep disturbance. PATIENTS/

methodsSleep disturbance was evaluated using the General Sleep Disturbance Scale six times over two cycles of chemotherapy. Latent profile analysis was used to identify subgroups of patients with distinct sleep disturbance profiles. Pathway impact analyses were performed in two independent samples using gene expression data obtained from RNA sequencing (n = 198) and microarray (n = 162) technologies. Fisher's combined probability test was used to identify significantly perturbed pathways between Low versus Very High sleep disturbance classes.

resultsIn the RNA sequencing and microarray samples, 59.1% and 51.9% of patients were in the Very High sleep disturbance class, respectively. Thirteen perturbed pathways were related to immune-inflammatory mechanisms (i.e., endocytosis, phagosome, antigen processing and presentation, natural killer cell mediated cytotoxicity, cytokine-cytokine receptor interaction, apoptosis, neutrophil extracellular trap formation, nucleotide-binding and oligomerization domain-like receptor signaling, Th17 cell differentiation, intestinal immune network for immunoglobulin A production, T-cell receptor signaling, complement and coagulation cascades, and tumor necrosis factor signaling).

conclusionsFirst study to identify perturbations in immune-inflammatory pathways associated with very high levels of sleep disturbance in oncology outpatients. Findings suggest that complex immune-inflammatory interactions underlie sleep disturbance.

Indexed as

NeoplasmsSleep Wake DisordersCytokinesHumansOutpatientsSleepCytokinesCancerChemotherapyImmune mechanismsInflammationInsomniaPathway impact analysisSleep disturbance

Identifiers

PMID36470166
PMCPMC11200329
OpenAlexW4309761892

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.