Evidence map›Paper›PMID 36470133›Full record

ArticleNeurobiology of aging2023

Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort.

Sarah-Naomi James, Jennifer M Nicholas, Kirsty Lu, Ashvini Keshavan, Christopher A Lane, Thomas Parker, Sarah M Buchanan, Sarah E Keuss, Heidi Murray-Smith, Andrew Wong and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Does Ideal Blood Pressure Vary by Cognitive Domain? A UK Biobank Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Sarah-Naomi JamesMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK. Electronic address: Sarah.n.james@ucl.ac.uk.
Jennifer M NicholasDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, University of London, London, UK.
Kirsty LuDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Ashvini KeshavanDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Christopher A LaneDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Thomas ParkerDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute Centre for Care Research and Technology, Imperial College London, UK; Department of Medicine, Division of Brain Sciences, Imperial College London.
Sarah M BuchananDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Sarah E KeussDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Heidi Murray-SmithDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
David M CashDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute at UCL, University College London, London, UK.
Ian B MaloneDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Josephine BarnesDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Carole H SudreMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
William CoathDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Marc ModatDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Sebastien OurselinDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Sebastian J CrutchDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Diana KuhMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
Nick C FoxDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute at UCL, University College London, London, UK.
Jonathan M SchottMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute at UCL, University College London, London, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
UK Dementia Research Institute · GBMRC Unit for Lifelong Health and Ageing · GBKing's College London · GBUniversity of London · GB

Funding

Medical Research Council G0501262Medical Research Council MC_UU_00019/1Medical Research Council MC_UU_00019/2Medical Research Council MC_UU_00019/3Medical Research Council MC_UU_00019/4Medical Research Council MC_UU_12019/3
6 · The paper itself

Abstract

Few studies can address how adulthood cognitive trajectories relate to brain health in 70-year-olds. Participants (n = 468, 49% female) from the 1946 British birth cohort underwent 18F-Florbetapir PET/MRI. Cognitive function was measured in childhood (age 8 years) and across adulthood (ages 43, 53, 60-64 and 69 years) and was examined in relation to brain health markers of β-amyloid (Aβ) status, whole brain and hippocampal volume, and white matter hyperintensity volume (WMHV). Taking into account key contributors of adult cognitive decline including childhood cognition, those with greater Aβ and WMHV at age 70 years had greater decline in word-list learning memory in the preceding 26 years, particularly after age 60. In contrast, those with smaller whole brain and hippocampal volume at age 70 years had greater decline in processing search speed, subtly manifest from age 50 years. Subtle changes in memory and processing speed spanning 26 years of adulthood were associated with markers of brain health at 70 years of age, consistent with detectable prodromal cognitive effects in early older age.

Indexed as

Birth CohortCognitive DysfunctionAdultAgedAmyloid beta-PeptidesBrainCognitionFemaleHumansMaleAmyloid beta-PeptidesAmyloidBrain healthBrain volumeCognitionCognitive declineLife course

Identifiers

PMID36470133
PMCPMC10564626
OpenAlexW4306761489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.