The transcriptional activity of progestins used in contraception and menopausal hormone therapy via progesterone receptor A is dependent on the density of the receptor.

Meghan Cartwright, Renate Louw-du Toit, Donita Africander

Open access · greenAbstract read

In one paragraph

Article in Biochemical and biophysical research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.9field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Effects of prenatal exposure to synthetic sex hormones on neurodevelopment: a biological mechanism.Frontiers in molecular neuroscience · 2023
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Meghan CartwrightDepartment of Biochemistry, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa. Electronic address: meghancartwright22@gmail.com.

Renate Louw-du ToitDepartment of Biochemistry, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa. Electronic address: renate@sun.ac.za.

Donita AfricanderDepartment of Biochemistry, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa. Electronic address: drho@sun.ac.za.

Stellenbosch University · ZA

Funding

Combination treatment for protection against HIV1 and pregnancyR01HD083026 · NICHD · UNIVERSITY OF CAPE TOWN · PI HAPGOOD, JANET PATRICIA, HEL, ZDENEK · 2015 to 2019

$2.5M

NICHD NIH HHS R01 HD083026

6 · The paper itself

Abstract

Studies directly comparing the efficacies and potencies of multiple progestins used in contraception and menopausal hormone therapy (MHT) in parallel via human progesterone receptor isoform A (PR-A) in the same model system are limited, and how these parameters are influenced by the density of PR-A are unclear. This is surprising as it is known that the expression levels of PR-A vary in different tissues and diseases. We thus determined for the first time the relative efficacies and potencies for transactivation of the natural PR ligand, progesterone (P

Indexed as

ProgestinsReceptors, ProgesteroneContraceptionFemaleHumansMenopauseProgesteroneProgesterone CongenersPromegestoneTranscription, GeneticProgesteroneProgesterone Congenersprogesterone receptor AProgestinsPromegestoneReceptors, ProgesteroneBreast cancerProgesterone receptor AProgestinsReceptor densityTransactivationTransrepression

Identifiers

PMID36470074

DOI10.1016/j.bbrc.2022.11.077

PMCPMC9876880

OpenAlexW4310154820

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.