Evidence map›Paper›PMID 36469976›Full record

ReviewClinical psychology review2023

Does the severity of autism symptoms change over time? A review of the evidence, impacts, and gaps in current knowledge.

Einat Waizbard-Bartov, Meghan Miller

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical psychology review, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Eye Tracking as a Treatment Monitoring Tool for Autism: A Multilevel Meta-Analysis.Autism research : official journal of the International Society for Autism Research · 2025
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. The Unique Roles of Executive Function in Co-Occurring Psychopathologies in Autism.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  8. Substance Use Disorder Outcomes and Treatment by Autism Status in Medicaid Enrollees With Substance Use Disorder.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Trajectories of autism symptom severity for boys and girls across childhood.Autism : the international journal of research and practice · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Einat Waizbard-BartovDepartment of Psychology, University of California Davis, Davis, CA, USA; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA. Electronic address: ewaizbar@ucdavis.edu.
Meghan MillerMIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA.

Funding

An investigation of transdiagnostic mechanisms underlying ASD and ADHD traits among infants at riskR01MH121416 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, MEGHAN RHYS · 2020 to 2024
$3.9M
Shared and Distinct Developmental Pathways to ADHD and Autism Spectrum DisorderR00MH106642 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, MEGHAN RHYS · 2017 to 2020
$863k
NIMH NIH HHS R00 MH106642NIMH NIH HHS R01 MH121416
6 · The paper itself

Abstract

Studies evaluating change in autism symptom severity across the lifespan have yielded inconsistent results, making it difficult to assess the prevalence of meaningful change in autism symptom severity, and what characterizes it. Better understanding the ways in which autism symptoms change over time is crucial, with important implications for intervention. Synthesizing information across past studies, autism symptom severity change (especially decreases) appears common, though stability of symptoms is also frequent. Symptom severity change is characterized by variability in patterns of change between different individuals (between-person), variability in change within a person's trajectory across time (within-person), and variability in change patterns across symptom domains (i.e., social-communication, restricted/repetitive behaviors). Variability in severity change is likely impacted by differences in person-level characteristics (e.g., sex, IQ, sociodemographic factors) as well as developmental processes across time. Numerous methodological issues may impact our ability to understand how common change in symptom severity is, including varying measurement tools, analytic approaches, and change patterns between symptom domains across time. Potential implications of better understanding and characterizing symptom severity change include incorporation of severity change patterns and predictors of change into research on biomarkers, and consideration of such predictors as moderators or mediators of change in clinical practice.

Indexed as

Autistic DisorderHumansSeverity of Illness IndexAutism spectrum disorderAutism symptom severitySymptom severity changeSymptom trajectories

Identifiers

PMID36469976
PMCPMC10357465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.