Evidence map›Paper›PMID 36469955›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

The Expression of Hypoxia-Related Biomarkers: A Significance of HIF-1α C1772T Polymorphism as Predictor of Laryngeal Carcinoma Relapse.

Miljan M Folic, Ana V Banko, Vera N Todorovic, Nela S Puskas, Jovica P Milovanovic, Sanja B Krejovic, Neda Z Dragicevic-Babic, Zoran M Bukumiric, Biljana R Milicic, Ana D Jotic and 1 more

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Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Miljan M FolicFaculty of Medicine, 119081University of Belgrade, Belgrade, Serbia.ORCID 0000-0002-6049-0342
Ana V BankoFaculty of Medicine, 119081University of Belgrade, Belgrade, Serbia.
Vera N TodorovicDepartment of Histology and Embryology, School of Medicine of University of Zenica, Zenica, Bosnia and Herzegovina.
Nela S PuskasFaculty of Medicine, 119081University of Belgrade, Belgrade, Serbia.
Jovica P MilovanovicFaculty of Medicine, 119081University of Belgrade, Belgrade, Serbia.
Sanja B KrejovicFaculty of Medicine, 119081University of Belgrade, Belgrade, Serbia.
Neda Z Dragicevic-BabicCenter for Rare Diseases - Reference Center Northern Bavaria (ZESE), 27207University Hospital Wuerzburg, Wurzburg, Germany.
Zoran M BukumiricFaculty of Medicine, 119081University of Belgrade, Belgrade, Serbia.
Biljana R MilicicStatistics and Informatics, School of Dental Medicine, 119082University of Belgrade, Belgrade, Serbia.
Ana D JoticFaculty of Medicine, 119081University of Belgrade, Belgrade, Serbia.
Vojko B DjukicFaculty of Medicine, 119081University of Belgrade, Belgrade, Serbia.
University of Belgrade · RSUniversitätsklinikum Würzburg · DEUniversity of Zenica · BA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe association between the expression of HIF-1α in the laryngeal carcinoma and the prognosis of disease is quite well documented, but the significance of HIF-1α C1772T polymorphism and its relation to disease phenotype have to be clarified. The aim of this study was to investigate the influence of C1772T polymorphism on the clinical-pathological characteristics and disease-free survival after initial surgical treatment of patients with laryngeal carcinoma. MATERIALS AND

methodsThe prospective cohort study included 65 patients with laryngeal carcinoma. Two representative tumor tissue specimens were taken in each patient during surgery; 1 specimen was used to asses HIF-1α C1772T polymorphism and the other 1 to determine the immunohistochemical expression of HIF-1α, VEGF, as well as CD 34 proteins. The comparison of polymorphism frequency between study and control population was conducted by collecting a 5 mL of peripheral venous blood samples in each subject.

resultsClinicopathological characteristics of laryngeal carcinoma didn't affect the expression of hypoxia-related biomarkers, such as HIF-1α, VEGF or MVD. The statistically significant association between HIF-1α and VEGF expression was found (

conclusionHIF-1α C1772T polymorphism was significantly associated with worse disease-free survival which nominates it as a predictor of laryngeal carcinoma relapse. The preoperative assessment of hypoxia-related biomarkers should be used in everyday practice in order to determine the treatment modalities for laryngeal carcinoma.

Indexed as

CarcinomaHypoxia-Inducible Factor 1, alpha SubunitLaryngeal NeoplasmsBiomarkersHumansHypoxiaNeoplasm Recurrence, LocalProspective StudiesVascular Endothelial Growth Factor ABiomarkersHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitVascular Endothelial Growth Factor Ahypoxia-inducible factor 1laryngeal squamous cell carcinomamicrovascular densitypolymorphismrecurrencevascular endothelial growth factor

Identifiers

PMID36469955
PMCPMC9730002
OpenAlexW4311502764

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.