Trial reportJournal of the American Medical Informatics Association : JAMIA2023
Efficacy of an mHealth self-management intervention for persons living with HIV: the WiseApp randomized clinical trial.
Trial report in Journal of the American Medical Informatics Association : JAMIA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Effectiveness of Telehealth in HIV Management for People Living with HIV and Key Populations: A Systematic Review of Models, Adherence, Viral Suppression, and Behavioral Outcomes.AIDS and behavior · 2026Pooled it
- Antiretroviral Therapy Adherence Interventions in the Era of Universal Test and Treat: A Hybrid Systematic-Narrative Literature Review of Global Evidence.AIDS and behavior · 2026Pooled it
- Effectiveness of Mobile Health Intervention in Medication Adherence: a Systematic Review and Meta-Analysis.Journal of medical systems · 2025Pooled it
- Efficacy of CHAMPS for Improving Viral Suppression: A Randomised Clinical Trial.AIDS and behavior · 2025Trial
- Differential Effects of Substance Use on HIV Care and Symptom Outcomes: A Longitudinal Analysis Among People with HIV.AIDS patient care and STDs · 2025Trial
- Feasibility and Acceptability of the Sense2Quit App for Improving Smoking Cessation in PWH.AIDS and behavior · 2025Trial
- A Remote Intervention Based on mHealth and Community Health Workers for Antiretroviral Therapy Adherence in People With HIV: Pilot Randomized Controlled Trial.JMIR formative research · 2025Trial
- The effect of a combined mHealth and community health worker intervention on HIV self-management.Journal of the American Medical Informatics Association : JAMIA · 2025Trial
- A Web-Based Antiretroviral Therapy Adherence Intervention (Thrive With Me) in a Community-Recruited Sample of Sexual Minority Men Living With HIV: Results of a Randomized Controlled Study.Journal of medical Internet research · 2024Trial
- Participatory Development and Concept Testing of mHealth Messaging to Support Care Engagement and Antiretroviral Therapy Adherence for Women Living With HIV in the Southern United States: Focus Group Study.JMIR formative research · 2025Article
- Acceptability and perceived usefulness of the CHAMPS intervention for improving medication adherence among people with HIV in Alabama and New York.International journal of medical informatics · 2025Article
- Development of a peer support and precision matching mobile platform for health management for people living with HIV.International journal of nursing sciences · 2025Article
- Evaluating the Usability of a Mobile Health Technology to Enhance Medication Adherence in People with HIV.Studies in health technology and informatics · 2025Article
- Developing and Implementing Provider-Training and Evidence-Based Tools to Support Pre-exposure Prophylaxis (PrEP) Decision-Making and Increase PrEP Adherence Among Young Men Who Have Sex With Men: Protocol for the PrEP Choice Longitudinal Cohort Study.JMIR research protocols · 2025Article
- Enhancing HIV Cognitive Abilities and Self-Management Through Information Technology-Assisted Interventions: Scoping Review.Journal of medical Internet research · 2025Article
- Social Marketing Perspective on Participant Recruitment in Informatics-Based Intervention Studies.AIDS and behavior · 2024Article
- Development and Testing of the WiseApp for Improving Medication Adherence Among Spanish Speakers.Studies in health technology and informatics · 2024Article
- Comparison of evaluation methods for improving the usability of a Spanish mHealth tool.International journal of medical informatics · 2024Article
- Development and evaluation of visualizations of smoking data for integration into the Sense2Quit app for tobacco cessation.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- A randomized controlled trial of the dissemination of an mHealth intervention for improving health outcomes: the WiseApp for Spanish-speakers living with HIV study protocol.BMC public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
importanceProgression of HIV disease, the transmission of the disease, and premature deaths among persons living with HIV (PLWH) have been attributed foremost to poor adherence to HIV medications. mHealth tools can be used to improve antiretroviral therapy (ART) adherence in PLWH and have the potential to improve therapeutic success.
objectiveTo determine the efficacy of WiseApp, a user-centered design mHealth intervention to improve ART adherence and viral suppression in PLWH. DESIGN, SETTING, AND
participantsA randomized (1:1) controlled efficacy trial of the WiseApp intervention arm (n = 99) versus an attention control intervention arm (n = 101) among persons living with HIV who reported poor adherence to their treatment regimen and living in New York City.
interventionsThe WiseApp intervention includes the following components: testimonials of lived experiences, push-notification reminders, medication trackers, health surveys, chat rooms, and a "To-Do" list outlining tasks for the day. Both study arms also received the CleverCap pill bottle, with only the intervention group linking the pill bottle to WiseApp.
resultsWe found a significant improvement in ART adherence in the intervention arm compared to the attention control arm from day 1 (69.7% vs 48.3%, OR = 2.5, 95% CI 1.4-3.5, P = .002) to day 59 (51.2% vs 37.2%, OR = 1.77, 95% CI 1.0-1.6, P = .05) of the study period. From day 60 to 120, the intervention arm had higher adherence rates, but the difference was not significant. In the secondary analyses, no difference in change from baseline to 3 or 6 months between the 2 arms was observed for all secondary outcomes.
conclusionsThe WiseApp intervention initially improved ART adherence but did not have a sustained effect on outcomes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.