Evidence map›Paper›PMID 36469774›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

CREBB repression of protein synthesis in mushroom body gates long-term memory formation in

Hsuan-Wen Lin, Chun-Chao Chen, Ruei-Yu Jhang, Linyi Chen, J Steven de Belle, Tim Tully, Ann-Shyn Chiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Redox regulation of memory formation by Rrp1 inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hsuan-Wen LinBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chun-Chao ChenBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
Ruei-Yu JhangBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID 0000-0002-7435-8385
Linyi ChenBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
J Steven de BelleBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID 0000-0001-6378-3944
Tim TullyBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID 0000-0002-2058-9073
Ann-Shyn ChiangBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID 0000-0001-9668-7115
National Tsing Hua University · TWKaohsiung Medical University · TWUniversity of Nevada, Las Vegas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Learned experiences are not necessarily consolidated into long-term memory (LTM) unless they are periodic and meaningful. LTM depends on de novo protein synthesis mediated by cyclic AMP response element-binding protein (CREB) activity. In

Indexed as

Drosophila ProteinsMushroom BodiesAnimalsCyclic AMP Response Element-Binding ProteinDrosophilaDrosophila melanogasterMemory, Long-TermCyclic AMP Response Element-Binding ProteinDrosophila Proteins5-HT1ACREBBmemory consolidationmemory inhibitionmemory regulation

Identifiers

PMID36469774
PMCPMC9897441
OpenAlexW4310964729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.