Evidence map›Paper›PMID 36469516›Full record

ArticlePLoS neglected tropical diseases2022

Pregnancy outcomes after snakebite envenomations: A retrospective cohort in the Brazilian Amazonia.

Thaís P Nascimento, Alexandre Vilhena Silva-Neto, Djane Clarys Baia-da-Silva, Patrícia Carvalho da Silva Balieiro, Antônio Alcirley da Silva Baleiro, Jacqueline Sachett, Lisele Brasileiro, Marco A Sartim, Flor Ernestina Martinez-Espinosa, Fan Hui Wen and 5 more

Open access · goldAbstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Snakebite-Associated Infections: A Systematic Review and Meta-Analysis.The American journal of tropical medicine and hygiene · 2024
    Pooled it
  2. Review
  3. Article
  4. Snakebite Envenomations In The Brazilian Amazon: A Little Less Neglected.Revista da Sociedade Brasileira de Medicina Tropical · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. The Chinese guideline for management of snakebites.World journal of emergency medicine · 2024
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Thaís P NascimentoLeônidas & Maria Deane Institute, Oswaldo Cruz Foundation, Manaus, Amazonas, Brazil.
Alexandre Vilhena Silva-NetoAmazonas State University, Manaus, Amazonas, Brazil.
Djane Clarys Baia-da-SilvaLeônidas & Maria Deane Institute, Oswaldo Cruz Foundation, Manaus, Amazonas, Brazil.
Patrícia Carvalho da Silva BalieiroAmazonas State University, Manaus, Amazonas, Brazil.
Antônio Alcirley da Silva BaleiroLeônidas & Maria Deane Institute, Oswaldo Cruz Foundation, Manaus, Amazonas, Brazil.
Jacqueline SachettAmazonas State University, Manaus, Amazonas, Brazil.
Lisele BrasileiroAmazonas State University, Manaus, Amazonas, Brazil.
Marco A SartimAmazonas State University, Manaus, Amazonas, Brazil.
Flor Ernestina Martinez-EspinosaLeônidas & Maria Deane Institute, Oswaldo Cruz Foundation, Manaus, Amazonas, Brazil.
Fan Hui WenButantan Institute, São Paulo, Brazil.
Manuela B PuccaRoraima Federal University, Boa Vista, Roraima, Brazil.
Charles J GerardoDepartment of Emergency Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.
Vanderson S SampaioDr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, Amazonas, Brazil.
Priscila Ferreira de AquinoLeônidas & Maria Deane Institute, Oswaldo Cruz Foundation, Manaus, Amazonas, Brazil.
Wuelton M MonteiroAmazonas State University, Manaus, Amazonas, Brazil.ORCID 0000-0002-0848-1940
Fundação de Medicina Tropical · BRFundação Oswaldo Cruz · BRInstituto Butantan · BRDuke University · USUniversidade Federal de Roraima · BR

Funding

Using community health centers to mitigate the impact of snakebite envenoming in low resource areasR21TW011944 · FIC · DUKE UNIVERSITY · PI GERARDO, CHARLES JOHN · 2021 to 2022
$534k
FIC NIH HHS R21 TW011944
6 · The paper itself

Abstract

Snakebite envenomations (SBEs) in pregnant women can result in adverse maternal or neonatal effects, such as abortion, placental abruption, preterm labor, fetal malformations, and maternal, fetal or neonatal deaths. Despite the high incidence of SBEs in the Brazilian Amazon, there is no literature on the impact of SBEs on pregnancy outcomes. The objective of this study was to describe clinical epidemiology and outcomes associated with SBEs in women of childbearing age and pregnant women in the state of Amazonas, Western Brazilian Amazon, from 2007 to 2021. Information on the population was obtained from the Reporting Information System (SINAN), Mortality Information System (SIM) and Live Birth Information System (SINASC) for the period from 2007 to 2021. A total of 36,786 SBEs were reported, of which 3,297 (9%) involved women of childbearing age, and 274 (8.3%) involved pregnant women. Severity (7.9% in pregnant versus 8.7% in non-pregnant women) (P = 0.87) and case-fatality (0.4% in pregnant versus 0.3% in non-pregnant women) rates were similar between groups (P = 0.76). Pregnant women who suffered snakebites were at higher risk for fetal death (OR: 2.17, 95%CI: 1.74-2.67) and neonatal death (OR = 2.79, 95%CI: 2.26-3.40). This study had major limitations related to the completeness of the information on the pregnancy outcomes. Although SBE incidence in pregnant women is low in the Brazilian Amazon, SBEs increased the risk of fetal and neonatal deaths.

Indexed as

Perinatal DeathSnake BitesBrazilFemaleHumansInfant, NewbornPlacentaPregnancyPregnancy OutcomeRetrospective Studies

Identifiers

PMID36469516
PMCPMC9754599
OpenAlexW4310700162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.