Evidence map›Paper›PMID 36469184›Full record

ArticleArchives of osteoporosis2022

Fracture distribution in postmenopausal women: a FRISBEE sub-study.

Mugisha Aude, Body Jean-Jacques, Iconaru Laura, Baleanu Felicia, Charles Alexia, Rozenberg Serge, Surquin Mureille, Bergmann Pierre, Benoit Florence

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Article in Archives of osteoporosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mugisha AudeDepartment of Geriatrics, CHU Brugmann, Université Libre de Bruxelles, Place van Gehuchten 4, 1020, Laeken, Brussels, Belgium. aude.ndamama@gmail.com.
Body Jean-JacquesDepartment of Endocrinology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Iconaru LauraDepartment of Endocrinology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Baleanu FeliciaDepartment of Endocrinology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Charles AlexiaDepartment of Internal Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Rozenberg SergeDepartment of Gynecology-Obstetrics, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.
Surquin MureilleDepartment of Geriatrics, CHU Brugmann, Université Libre de Bruxelles, Place van Gehuchten 4, 1020, Laeken, Brussels, Belgium.
Bergmann PierreLaboratory of Translational Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Benoit FlorenceDepartment of Geriatrics, CHU Brugmann, Université Libre de Bruxelles, Place van Gehuchten 4, 1020, Laeken, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We registered 1336 incident-validated fractures in a prospective cohort of 3560 postmenopausal (60-85 years) Belgian women (mean follow-up of 9.1 years). The increase of fracture incidence with age varied widely depending on the fracture site and was significantly steeper for central than for peripheral fractures (e.g., not significant for the ankle).

introductionThe epidemiology of fracture sites other than MOFs has been less studied. We examined the incidence of fractures according to their sites in a prospective cohort of postmenopausal Belgian women.

methodsThree thousand five hundred sixty postmenopausal women, aged 60-85 years old, were recruited from 2007 to 2013 and surveyed yearly (FRISBEE). The number of validated incident fractures was recorded and analyzed in relation to age and the fracture site.

resultsOne thousand three hundred thirty-six fractures were recorded after a mean follow-up of 9.1 years. Seven hundred fifty-six fractures (57%) were MOFs and 580 (43%) non-MOFs, while 813 (61%) were central and 523 (39%) peripheral. The increase of fracture incidence with age differed between fracture sites and was steeper for central than for peripheral fractures. The ratio of MOFs to non-MOFs increased significantly with age, from 1.10 (95% CI: 0.83-1.45) for the 60-69 to 1.69 [1.42-2.01] for the 80-89-year subgroup (P = 0.017). This was also true for central versus peripheral fracture. We differentiated three groups of fracture incidence evolution with age: fractures with a mean increase/decade (compared to the 60-69 age group) of less than 1.5, 1.5-2.0, and 2.0-3.0. The lowest increase was seen for most peripheral fractures, whereas the greatest increase included hip, scapula, pelvis, ribs, and spine fractures.

conclusionThe increase of fracture incidence with age varied widely depending on the fracture site, and the ratio of MOFs to non-MOFs rose significantly with age. Some peripheral fractures, such as the ankle, did not increase significantly with age, suggesting that bone fragility does not play a major role in their occurrence.

Indexed as

Fractures, BoneOsteoporosis, PostmenopausalOsteoporotic FracturesSpinal FracturesAgedAged, 80 and overBone DensityFemaleHumansMiddle AgedPostmenopauseProspective StudiesRisk FactorsAgingCentral fractureElderly womenFracture epidemiologyMOFOsteoporosis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.