Evidence map›Paper›PMID 36469056›Full record

ReviewSeminars in immunopathology2023

Regulatory T lymphocytes as a therapy for ischemic stroke.

Miao Wang, Angus W Thomson, Fang Yu, Rimi Hazra, Aditi Junagade, Xiaoming Hu

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in immunopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  17. The influence of gender on CD4Frontiers in neurology · 2025
    Article
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  20. Co-transplantation of autologous treg cells: A groundbreaking cell therapy for brain diseases.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Miao WangGeriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, 15261, USA.
Angus W ThomsonDepartment of Surgery and Department of Immunology, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Fang YuPittsburgh Institute of Brain Disorders and Recovery and Department of Neurology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, SBST, Pittsburgh, PA, 15213, USA.
Rimi HazraPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Aditi JunagadePittsburgh Institute of Brain Disorders and Recovery and Department of Neurology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, SBST, Pittsburgh, PA, 15213, USA.
Xiaoming HuGeriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, 15261, USA. hux2@upmc.edu.ORCID 0000-0002-5857-6243
University of Pittsburgh · US

Funding

Transplant Pathology and Tissue Imaging Core (Core B)U19AI131453 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2017 to 2022
$8.4M
Regulatory Dendritic Cell Therapy in Live Donor Renal Transplant RecipientsU01AI136779 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2018 to 2022
$4.3M
Regulatory T cell as a restorative therapy for ischemic strokeR01NS094573 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SUN, DANDAN · 2016 to 2021
$1.7M
Interleukin-33 as an immune therapy for strokeI01BX003651 · VA · VETERANS HEALTH ADMINISTRATION · PI HU, XIAOMING · 2019 to 2023
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Novel immune therapy to promote functional recovery after traumatic brain injuryI01BX005589 · VA · VETERANS HEALTH ADMINISTRATION · PI Xiaoming Hu · 2023 to 2026
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BLRD VA I01 BX003651BLRD VA I01 BX005589NIAID NIH HHS U01 AI136779NIAID NIH HHS U19 AI131453NINDS NIH HHS R01 NS094573
6 · The paper itself

Abstract

Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4

Indexed as

Ischemic StrokeStrokeHumansImmunosuppressive AgentsT-Lymphocytes, RegulatoryImmunosuppressive AgentsBrain repairImmunoregulationNeuroprotectionRegulatory T cell

Identifiers

PMID36469056
PMCPMC10239790
OpenAlexW4310703116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.