ArticleArchives of endocrinology and metabolism2023
The threshold value for identifying insulin resistance (HOMA-IR) in an admixed adolescent population: A hyperglycemic clamp validated study.
Article in Archives of endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Revealing subject-specific temporal patterns from longitudinal data.Bioinformatics (Oxford, England) · 2026Article
- A distinct form of fat fibrosis is linked to insulin resistance in people with HIV.JCI insight · 2026Observational
- Expression of APOL1 and NOTCH2 genes in patients with type 2 diabetes mellitus attending babcock University Teaching Hospital, Ogun State, Nigeria.Scientific reports · 2026Article
- Use of C-peptide and homeostasis model assessment of insulin resistance to assess insulin resistance in dogs.Journal of veterinary internal medicine · 2026Article
- Article
- Long-term endocrine and testicular outcomes in male survivors of childhood acute lymphoblastic leukemia.Journal of endocrinological investigation · 2026Article
- The relationship between obstructive sleep apnea and insulin resistance in patients with type 2 diabetes mellitus: a cross-sectional observational study.Journal of thoracic disease · 2026Article
- Galectin-1, Adiponectin, Leptin, and the Adiponectin to Leptin Ratio as Predictors of Metabolic Syndrome: Influence of Age and Body Mass Index.BioMed research international · 2026Article
- Article
- Insulin resistance with associated hyperinsulinemia as a risk factor for the development and worsening of HFpEF.Frontiers in cardiovascular medicine · 2026Review
- Insulin Resistance at the Crossroads of Metabolic Inflammation, Cardiovascular Disease, Organ Failure and Cancer.Biomolecules · 2025Review
- Observational
- Glucose metabolism in heterozygous familial hypercholesterolemia with a founder effect and a high diabetes prevalence: a cross-sectional study.Cardiovascular diabetology · 2025Article
- Sex Differences in Body Composition and MASLD in Children With Overweight and Obesity.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Association between the combination of the triglyceride-glucose index and obesity-related indices with hyperuricemia among children and adolescents in China.Lipids in health and disease · 2025Article
- Reduction of insulin resistance in 14-15-year-old students after the COVID-19 pandemic: a prospective study from Tsunan, Japan.Frontiers in clinical diabetes and healthcare · 2025Article
- Changes in insulin resistance and other metabolic parameters during home quarantine amid the COVID-19 pandemic among the general population.Frontiers in nutrition · 2025Article
- Body composition shapes cardiometabolic risk in children with multifactorial dyslipidemia.Frontiers in nutrition · 2025Article
- Biochemical study of the risk of diabetes, prediabetic and insulin resistance in car painters and its association with mercury exposure: a retrospective case-control study.Toxicology research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To validate the homeostasis model assessment (HOMA) of insulin resistance (IR) as a surrogate to the hyperglycemic clamp to measure IR in both pubertal and postpubertal adolescents, and determine the HOMA-IR cutoff values for detecting IR in both pubertal stages. Subjects and methods: The study sample comprised 80 adolescents of both sexes (aged 10-18 years; 37 pubertal), in which IR was assessed with the HOMA-IR and the hyperglycemic clamp. Results: In the multivariable linear regression analysis, adjusted for sex, age, and waist circumference, the HOMA-IR was independently and negatively associated with the clamp-derived insulin sensitivity index in both pubertal (unstandardized coefficient - B = -0.087, 95% confidence interval [CI] = -0.135 to -0.040) and postpubertal (B = -0.101, 95% CI, -0.145 to -0.058) adolescents. Bland-Altman plots showed agreement between the predicted insulin sensitivity index and measured clamp-derived insulin sensitivity index in both pubertal stages (mean =-0.00 for pubertal and postpubertal); all Conclusion: The threshold value of the HOMA-IR for identifying insulin resistance was > 3.22 for pubertal and > 2.91 for postpubertal adolescents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.