Evidence map›Paper›PMID 36468875›Full record

ArticleAntimicrobial agents and chemotherapy2023

Antimicrobial Susceptibility Testing Performed in RPMI 1640 Reveals Azithromycin Efficacy against Carbapenem-Resistant Acinetobacter baumannii and Predicts

Sarah Miller, Kristine Goy, Rosemary She, Brad Spellberg, Brian Luna

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Ceftazidime retainsmSphere · 2025
    Article
  7. Article
  8. Review
  9. Polymyxins retainAntimicrobial agents and chemotherapy · 2024
    Article
  10. Treatment Strategies of Colistin ResistanceAntibiotics (Basel, Switzerland) · 2024
    Review
  11. Microorganisms · 2023
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah MillerDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.ORCID 0000-0002-1441-4015
Kristine GoyDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
Rosemary SheDepartment of Pathology, Keck School of Medicine at USC, Los Angeles, California, USA.
Brad SpellbergLos Angeles County-USC Medical Center, Los Angeles, California, USA.
Brian LunaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.ORCID 0000-0001-6718-4551

Funding

MAb Passive Vaccination against Acinetobacter baumanniiR01AI130060 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRAD J SPELLBERG · 2017 to 2026
$6.7M
Characterization of Rifabutin Therapy Against Antibiotic-Resistant BacteriaR01AI139052 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUNA, BRIAN MICHAEL · 2018 to 2021
$2.4M
NIAID NIH HHS R01 AI130060NIAID NIH HHS R01 AI139052
6 · The paper itself

Abstract

Antimicrobial susceptibility testing (AST) in RPMI 1640, a more physiologically relevant culture medium, revealed that a substantial proportion of carbapenem-resistant Acinetobacter baumannii isolates were susceptible to azithromycin, a macrolide antibiotic not currently considered effective against A. baumannii. Experiments using Galleria mellonella validated these

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsMothsAnimalsAnti-Bacterial AgentsAzithromycinCarbapenemsColistinDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAzithromycinCarbapenemsColistinAcinetobacter baumanniiantibiotic resistanceazithromycincolistin

Identifiers

PMID36468875
PMCPMC9872712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.