Evidence map›Paper›PMID 36468624›Full record

ArticleMagnetic resonance in medicine2023

An untrained deep learning method for reconstructing dynamic MR images from accelerated model-based data.

Kalina P Slavkova, Julie C DiCarlo, Viraj Wadhwa, Sidharth Kumar, Chengyue Wu, John Virostko, Thomas E Yankeelov, Jonathan I Tamir

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kalina P SlavkovaDepartment of Physics, The University of Texas, Austin, Texas, USA.ORCID 0000-0003-4311-2355
Julie C DiCarloThe Oden Institute for Computational Engineering and Sciences, The University of Texas, Austin, Texas, USA.ORCID 0000-0002-6965-3611
Viraj WadhwaChandra Family Department of Electrical and Computer Engineering, The University of Texas, Austin, Texas, USA.
Sidharth KumarChandra Family Department of Electrical and Computer Engineering, The University of Texas, Austin, Texas, USA.
Chengyue WuThe Oden Institute for Computational Engineering and Sciences, The University of Texas, Austin, Texas, USA.ORCID 0000-0002-3789-404X
John VirostkoThe Oden Institute for Computational Engineering and Sciences, The University of Texas, Austin, Texas, USA.
Thomas E YankeelovThe Oden Institute for Computational Engineering and Sciences, The University of Texas, Austin, Texas, USA.
Jonathan I TamirThe Oden Institute for Computational Engineering and Sciences, The University of Texas, Austin, Texas, USA.ORCID 0000-0001-9113-9566

Funding

Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
INTEGRATING OMICS AND QUANTITATIVE IMAGING DATA IN CO-CLINICAL TRIALS TO PREDICT TREATMENT RESPONSE IN TRIPLE NEGATIVE BREAST CANCERU24CA226110 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LEWIS, MICHAEL T., RUBIN, DANIEL L · 2019 to 2023
$3.2M
Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast CancerU01CA174706 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, YANKEELOV, THOMAS E · 2013 to 2018
$2.5M
Using label-free Raman microscopy to predict therapeutic resistance of TNBC cellsU01CA253540 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI BROCK, AMY, YANKEELOV, THOMAS E · 2020 to 2024
$2.1M
Personalizing immunotherapy in HER2+ breast cancer through quantitative imagingR01CA240589 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SORACE, ANNA C · 2020 to 2023
$1.6M
Interoperable Software Platform for Reproducible Research and Clinical Translation of MRIU24EB029240 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI LUSTIG, MICHAEL, UECKER, MARTIN · 2019 to 2023
$1.6M
NCI NIH HHS R01 CA240589NCI NIH HHS U01 CA142565NCI NIH HHS U01 CA174706NCI NIH HHS U01 CA253540NCI NIH HHS U24 CA226110NIBIB NIH HHS U24 EB029240
6 · The paper itself

Abstract

purposeTo implement physics-based regularization as a stopping condition in tuning an untrained deep neural network for reconstructing MR images from accelerated data.

methodsThe ConvDecoder (CD) neural network was trained with a physics-based regularization term incorporating the spoiled gradient echo equation that describes variable-flip angle data. Fully-sampled variable-flip angle k-space data were retrospectively accelerated by factors of R = {8, 12, 18, 36} and reconstructed with CD, CD with the proposed regularization (CD + r), locally low-rank (LR) reconstruction, and compressed sensing with L1-wavelet regularization (L1). Final images from CD + r training were evaluated at the "argmin" of the regularization loss; whereas the CD, LR, and L1 reconstructions were chosen optimally based on ground truth data. The performance measures used were the normalized RMS error, the concordance correlation coefficient, and the structural similarity index.

resultsThe CD + r reconstructions, chosen using the stopping condition, yielded structural similarity indexs that were similar to the CD (p = 0.47) and LR structural similarity indexs (p = 0.95) across R and that were significantly higher than the L1 structural similarity indexs (p = 0.04). The concordance correlation coefficient values for the CD + r T

conclusionThe use of an untrained neural network together with a physics-based regularization loss shows promise as a measure for determining the optimal stopping point in training without relying on fully-sampled ground truth data.

Indexed as

Deep LearningImage Processing, Computer-AssistedHumansMagnetic Resonance ImagingNeural Networks, ComputerRetrospective Studiesimage reconstructioninverse problemphysics-guided deep learningquantitative MRI

Identifiers

PMID36468624
PMCPMC9892348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.