ArticleJournal of periodontal & implant science2023
Tissue integration patterns of non-crosslinked and crosslinked collagen membranes: an experimental
Article in Journal of periodontal & implant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 10 citations in OpenAlex.
- Hard and soft tissue contour changes following simultaneous guided bone regeneration at single peri-implant dehiscence defects using either resorbable or non-resorbable membranes: a 6-month secondary analysis of a randomized controlled trial.Clinical oral investigations · 2025Trial
- Biodegradable Guided Bone Regeneration Membranes for Periodontal Regeneration in Dogs.Dentistry journal · 2026Review
- Do collagen membranes with different thickness-related mechanical properties affect the outcomes of lateral bone augmentation? An immunohistochemical analysis.Clinical oral investigations · 2026Article
- Effect of pseudo-periosteum on hard and soft tissue regeneration following lateral bone augmentation using a titanium mesh: an experimentalJournal of periodontal & implant science · 2026Article
- Evaluation of the Effectiveness of the Socket Preservation Technique Using Allogeneic and Xenogeneic Materials: A Randomized Controlled Trial.Journal of functional biomaterials · 2026Article
- 1st Global Consensus for Clinical Guidelines for the Rehabilitation of the Edentulous Maxilla: A Single-Round Survey on Sinus Lift and Alveolar Bone Augmentation Techniques.Clinical oral implants research · 2026Article
- Does Early Re-Entry Surgery Following Simultaneous Guided Bone Regeneration Compromise the Dimension of Peri-Implant Tissues?Journal of clinical periodontology · 2025Article
- Comparison of four bone substitute types in sinus augmentation with perforated Schneiderian membrane: An experimental study.Journal of periodontology · 2025Article
- The efficacy of a novel porcine-derived collagen membrane on guided bone regeneration: a comparative study in canine model.BMC oral health · 2025Article
- Biomaterials for Guided Tissue Regeneration and Guided Bone Regeneration: A Review.Dentistry journal · 2025Review
- Bone regeneration using activin A/BMP2 chimera (AB204) with collagen membrane in rats with calvarial defects.Journal of periodontal & implant science · 2024Article
- A Flexible Membrane May Improve Bone Regeneration by Increasing Hydrophilicity and Conformability in Lateral Bone Augmentation.Biomaterials research · 2024Article
- Occlusive membranes for guided regeneration of inflamed tissue defects.Nature communications · 2023Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeNon-crosslinked and crosslinked collagen membranes are known to exhibit distinct degradation characteristics, resulting in contrasting orientations of the adjacent tissues and different biological processes. The aim of this study was to conduct a histomorphometric assessment of non-crosslinked and crosslinked collagen membranes regarding neovascularization, tissue integration, tissue encapsulation, and biodegradation.
methodsGuided bone regeneration was performed using either a non-crosslinked (BG) or a crosslinked collagen membrane (CM) in 15 beagle dogs, which were euthanized at 4, 8, and 16 weeks (n=5 each) for histomorphometric analysis. The samples were assessed regarding neovascularization, tissue integration, encapsulation, the remaining membrane area, and pseudoperiosteum formation. The BG and CM groups were compared at different time periods using nonparametric statistical methods.
resultsThe remaining membrane area of CM was significantly greater than that of BG at 16 weeks; however, there were no significant differences at 4 and 8 weeks. Conversely, the neovascularization score for CM was significantly less than that for BG at 16 weeks. BG exhibited significantly greater tissue integration and encapsulation scores than CM at all time periods, apart from encapsulation at 16 weeks. Pseudoperiosteum formation was observed in the BG group at 16 weeks.
conclusionsAlthough BG membranes were more rapidly biodegraded than CM membranes, they were gradually replaced by connective tissue with complete integration and maturation of the surrounding tissues to form dense periosteum-like connective tissue. Further studies need to be performed to validate the barrier effect of the pseudoperiosteum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.