Evidence map›Paper›PMID 36467966›Full record

ArticleJTO clinical and research reports2022

Viral Mimicry Response Is Associated With Clinical Outcome in Pleural Mesothelioma.

Suna Sun, Weihong Qi, Hubert Rehrauer, Manuel Ronner, Ananya Hariharan, Martin Wipplinger, Clément Meiller, Rolf Stahel, Martin Früh, Ferdinando Cerciello and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTO clinical and research reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Endogenous Retroviruses as Modulators of Innate Immunity.Pathogens (Basel, Switzerland) · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Suna SunLaboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
Weihong QiFunctional Genomics Center, ETH Zurich, University of Zurich, Zurich, Switzerland.
Hubert RehrauerFunctional Genomics Center, ETH Zurich, University of Zurich, Zurich, Switzerland.
Manuel RonnerLaboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
Ananya HariharanLaboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
Martin WipplingerLaboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
Clément MeillerCentre de Recherche des Cordeliers, Inserm, Sorbonne Université, Université Paris Cité, Functional Genomics of Solid Tumors, Paris, France.
Rolf StahelCoordinating Center, European Thoracic Oncology Platform (ETOP), Bern, Switzerland.
Martin FrühSwiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland.
Ferdinando CercielloDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jean-François FonteneauNantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.
Didier JeanCentre de Recherche des Cordeliers, Inserm, Sorbonne Université, Université Paris Cité, Functional Genomics of Solid Tumors, Paris, France.
Emanuela Felley-BoscoLaboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHInserm · FRUniversity of Bern · CHUniversity of Zurich · CHCentre National de la Recherche Scientifique · FRSwiss Group For Clinical Cancer Research · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of this study was to investigate endogenous retrovirus (ERV) expression and type I interferon (IFN) activation in human pleural mesothelioma (PM) and their association with clinical outcome. Methods: The expression of ERV was determined from PM cohorts and mesothelial precursor RNA sequencing data. The expression of ERV was confirmed by quantitative polymerase chain reaction (qPCR). Methylation of genomic DNA was assessed by quantitative methylation-specific PCR. DNA demethylation was induced in cells by demethylating agent 5-Aza-2'-deoxycytidine (5-Aza-CdR) treatment. To block type I IFN signaling, the cells were treated with ruxolitinib or MAVS silencing. The expression of IFN-stimulated genes (ISGs) was determined by qPCR and Western blot. Circulating ERVs were detected by qPCR. Results: Long terminal repeats (LTRs) represent the most abundant transposable elements up-regulated in PM. Within the LTR, Conclusions: We provide clues for patient stratification especially for immunotherapy where best clinical responses are associated with an activated basal immune response.

Indexed as

BRCA-associated protein 1Endogenous retrovirusesPleural mesotheliomaType I interferon

Identifiers

PMID36467966
PMCPMC9709230
OpenAlexW4308458443

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.