Evidence map›Paper›PMID 36467913›Full record

ArticleACS omega2022

Bijels as a Fluid Labyrinth for Drugs: The Effect of Nanoparticles on the Release Kinetics of Ethosuximide and Dimethyl Fumarate.

Valeria Vanoli, Giovanna Massobrio, Fabio Pizzetti, Andrea Mele, Filippo Rossi, Franca Castiglione

Abstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Valeria VanoliDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy.
Giovanna MassobrioDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy.
Fabio PizzettiDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy.
Andrea MeleDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy.ORCID https://orcid.org/0000-0002-0351-0538
Filippo RossiDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy.ORCID https://orcid.org/0000-0003-2665-120X
Franca CastiglioneDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy.ORCID https://orcid.org/0000-0003-2413-8808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bijels (bicontinuous interfacially jammed emulsion gels) raised an increasing interest as biomaterials for controlled drug delivery due to their biphasic nature organized in mesoscopic tortuous domains. Two bijel formulations were prepared and explored as delivery systems for both hydrophilic and lipophilic drugs, ethosuximide and dimethyl fumarate. The two bijel-like structures, based on polymerized ε-caprolactone/water, differ in the stabilizing nanoparticle hydroxyapatite (inorganic) and nanogel-based nanoparticles (organic). Diffusion nuclear magnetic resonance spectroscopy has been used to characterize the bijel structure and the transport behavior of the drug molecules confined within the water/organic interconnected domains. A reduced diffusion coefficient is observed for several concentrations of the drugs and both bijel formulations. Moreover,

Identifiers

PMID36467913
PMCPMC9713867

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.