Evidence map›Paper›PMID 36467891›Full record

ArticleBioMed research international2022

Identification and Validation of Common Reference Genes for Normalization of Esophageal Squamous Cell Carcinoma Gene Expression Profiles.

Jia Xu, Ming Yang, Ai-Zhong Shao, Hui-Wen Pan, Yi-Xuan Fan, Ke-Ping Chen

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jia XuSchool of Life Sciences, Jiangsu University, Zhenjiang, China.ORCID https://orcid.org/0000-0003-3020-3848
Ming YangDepartment of General Surgery, Fifth People's Hospital of Huaian City, Huaian, China.ORCID https://orcid.org/0000-0002-3977-3487
Ai-Zhong ShaoDepartment of Cardiothorac Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.ORCID https://orcid.org/0000-0003-3298-3796
Hui-Wen PanDepartment of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.ORCID https://orcid.org/0000-0003-0443-5063
Yi-Xuan FanSchool of Life Sciences, Jiangsu University, Zhenjiang, China.ORCID https://orcid.org/0000-0002-9827-0177
Ke-Ping ChenSchool of Life Sciences, Jiangsu University, Zhenjiang, China.ORCID https://orcid.org/0000-0001-5254-2299
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the subtypes of esophageal cancer with Chinese characteristics, and its five-year survival rate is less than 20%. Early diagnosis is beneficial to improving the survival rate of ESCC significantly. Quantitative Real-Time Polymerase Chain Reaction is a high-throughput technique that can quantify tumor-related genes for early diagnosis. Its accuracy largely depends on the stability of the reference gene. There is no systematic scientific basis to demonstrate which reference gene expression is stable in ESCC and no consensus on the selection of internal reference. Therefore, this research used four software programs (

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaExome SequencingGene Expression ProfilingHumansTranscriptome

Identifiers

PMID36467891
PMCPMC9711964
OpenAlexW4309912686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.