Evidence map›Paper›PMID 36467794›Full record

ArticleEJHaem2022

Bortezomib-based therapy is effective and well tolerated in frontline and multiply pre-treated Waldenström macroglobulinaemia including BTKi failures: A real-world analysis.

Jahanzaib Khwaja, Encarl Uppal, Robert Baker, Kajal Trivedi, Ali Rismani, Rajeev Gupta, Ian Proctor, Charalampia Kyriakou, Shirley D'Sa

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jahanzaib KhwajaDepartment of Haematology University College London Hospitals London UK.ORCID https://orcid.org/0000-0002-4993-7828
Encarl UppalDepartment of Haematology University College London Hospitals London UK.
Robert BakerHealth Services Laboratories London UK.
Kajal TrivediHealth Services Laboratories London UK.
Ali RismaniDepartment of Haematology University College London Hospitals London UK.
Rajeev GuptaDepartment of Haematology University College London Hospitals London UK.
Ian ProctorDepartment of Cellular Pathology University College London Hospitals London UK.
Charalampia KyriakouDepartment of Haematology University College London Hospitals London UK.
Shirley D'SaDepartment of Haematology University College London Hospitals London UK.
University College London Hospitals NHS Foundation Trust · GBUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Waldenström macroglobulinemia (WM) is a rare, incurable low grade lymphoma following a relapsing trajectory. Management strategies have evolved with the introduction of targeted therapy including new classes of Bruton tyrosine kinase inhibitor (BTKi). Treatment may however be limited particularly at relapse by a lack of drug availability and tolerability. We assessed the real-world efficacy and tolerability of bortezomib-containing regimens in patients with WM at frontline and relapse including those with prior BTKi resistance. Forty-one patients were identified with 44 bortezomib-containing regimens administered (

Indexed as

bortezomibBTKilymphoplasmacytic lymphomaWaldenström macroglobulinaemia

Identifiers

PMID36467794
PMCPMC9713031
OpenAlexW4306925959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.