Evidence map›Paper›PMID 36467420›Full record

ReviewFrontiers in cell and developmental biology2022

Mechanosensing in macrophages and dendritic cells in steady-state and disease.

Megan Lee, Huixun Du, Daniel A Winer, Xavier Clemente-Casares, Sue Tsai

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 81 citations in OpenAlex.

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  5. Piezo channels in tumors.Journal of cancer research and clinical oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Megan LeeDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Huixun DuBuck Institute for Research on Aging, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States.
Daniel A WinerDivision of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON, Canada.
Xavier Clemente-CasaresCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB, Canada.
Sue TsaiCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CABuck Institute for Research on Aging · US

Funding

USC-Buck Institute Nathan Shock Admin CoreP30AG068345 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI COHEN, PINCHAS, CURRAN, SEAN P · 2020 to 2024
$5.0M
NIA NIH HHS P30 AG068345
6 · The paper itself

Abstract

Macrophages and dendritic cells are myeloid cells that play critical roles in immune responses. Macrophages help to maintain homeostasis through tissue regeneration and the clearance of dead cells, but also mediate inflammatory processes against invading pathogens. As the most potent antigen-presenting cells, dendritic cells are important in connecting innate to adaptive immune responses

Indexed as

dendritic cellsHippo signallingintegrinsmacrophagesmechanotransductionPiezo1substrate stiffnessTRPV4

Identifiers

PMID36467420
PMCPMC9712790
OpenAlexW4309607982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.